Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1024611
rs1024611
0.010 GeneticVariation BEFREE Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities. 25413568

2015

dbSNP: rs1740073
rs1740073
0.010 GeneticVariation BEFREE Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting. 28765276

2017

dbSNP: rs2375981
rs2375981
0.010 GeneticVariation BEFREE Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting. 28765276

2017

dbSNP: rs2954029
rs2954029
0.010 GeneticVariation BEFREE In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI. 21071687

2011

dbSNP: rs6834314
rs6834314
0.010 GeneticVariation BEFREE We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS). 28007909

2017

dbSNP: rs6921438
rs6921438
0.010 GeneticVariation BEFREE Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting. 28765276

2017

dbSNP: rs872129
rs872129
0.010 GeneticVariation BEFREE High YKL-40 levels (>85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD. 22937056

2012

dbSNP: rs1239681664
rs1239681664
0.010 GeneticVariation BEFREE ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis. 25118983

2014

dbSNP: rs138880920
rs138880920
0.010 GeneticVariation BEFREE Heterozygosity for an ABCA1 mutation (K776N) conferred two- to three-fold risk of IHD in 37 participants in the Copenhagen City Heart study. 16226177

2005

dbSNP: rs2066714
rs2066714
0.010 GeneticVariation BEFREE A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs. 17951323

2008

dbSNP: rs2066718
rs2066718
0.010 GeneticVariation BEFREE A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs. 17951323

2008

dbSNP: rs2230808
rs2230808
0.010 GeneticVariation BEFREE Despite this, 5 out of 6 SNPs (V771M, V825I, I883M, E1172D, R1587K) predicted increased risk of IHD. 17951323

2008

dbSNP: rs33918808
rs33918808
0.010 GeneticVariation BEFREE A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs. 17951323

2008

dbSNP: rs4147929
rs4147929
0.010 GeneticVariation BEFREE Including 288,563 individuals, meta-analyzed odds ratios for ischemic heart disease per one allele <i>ABCA7</i> rs4147929 increase was 1.01 (0.99-1.03). 29376091

2018

dbSNP: rs1045642
rs1045642
0.010 GeneticVariation BEFREE ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis. 25118983

2014

dbSNP: rs72653706
rs72653706
0.010 GeneticVariation BEFREE In 4 studies including 66 831 participants and 13 642 cases with ischemic vascular events, heterozygosity for ABCC6 R1141X did not associate with risk of IHD, myocardial infarction, ICVD, or ischemic stroke. 21831958

2011

dbSNP: rs750249283
rs750249283
0.010 GeneticVariation BEFREE Next, we genotyped 10 237 individuals from the Copenhagen City Heart Study for the identified variants and determined the effect on lipid and lipoprotein levels and on risk of myocardial infarction (MI) and ischemic heart disease (IHD). g.-376C>T, g.-311T>A, and Ser630Leu predicted risk of MI in the Copenhagen City Heart Study, with hazard ratios of 2.2 (95% confidence interval: 1.2-4.3), 1.7 (1.0-2.9), and 7.5 (1.9-30), respectively. 22155456

2012

dbSNP: rs1800888
rs1800888
0.010 GeneticVariation BEFREE ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population. 21883537

2012

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group. 12805070

2003

dbSNP: rs699
rs699
AGT
0.020 GeneticVariation BEFREE In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease. 11352695

2001

dbSNP: rs4762
rs4762
AGT
0.010 GeneticVariation BEFREE In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease. 11352695

2001

dbSNP: rs567798234
rs567798234
0.010 GeneticVariation BEFREE Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease. 24431031

2014

dbSNP: rs12713559
rs12713559
0.010 GeneticVariation BEFREE Heterzygous carriers of the Arg3531Cys mutation in the general population did not have higher-than-normal plasma cholesterol levels or an increased risk of ischemic heart disease (odds ratio; 1.4; 95 percent confidence interval, 0.2 to 11; P=0.54). 9603795

1998

dbSNP: rs5742904
rs5742904
0.010 GeneticVariation BEFREE The Arg3500Gln mutation in the apolipoprotein B gene, which is responsible for familial defective apolipoprotein B-100 and is present in approximately 1 in 1000 persons in Denmark, causes severe hypercholesterolemia and increases the risk of ischemic heart disease. 9603795

1998

dbSNP: rs12817819
rs12817819
0.010 GeneticVariation BEFREE The ATP2B1 rs12817819 A allele is associated with increased risk for RHTN in hypertensive participants with documented CAD or suspected ischemic heart disease. 25385345

2014