rs1024611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Odds ratios (OR) with 95% confidence interval (CI) were used to evaluate the strength of associations between the MCP-1 A-2518G polymorphism (rs1024611) and IHD and IS susceptibilities.
|
25413568 |
2015 |
rs1740073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
rs2375981
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
rs2954029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the general population, both TRIB1-rs2954029 and GCKR-rs1260326 were associated with lipid levels, whereas TRIB1 was also associated with increased risk of IHD and MI.
|
21071687 |
2011 |
rs6834314
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We used instrumental variable analysis based on two single nucleotide polymorphism (SNPs) HSD17B13/MAPK10 (rs6834314) and PNPLA3/SAMM50 (rs738409) to assess the associations of ALT (U/L) with IHD, diabetes and other CVD risk factors in the Guangzhou Biobank Cohort Study (GBCS).
|
28007909 |
2017 |
rs6921438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Based on 9 SNPs independently predicting VEGF (rs1740073 [<i>C6orf223</i>], rs2375981 [<i>KCNV2</i>], rs2639990 [<i>ZADH2</i>], rs4782371 [<i>ZFPM1</i>], rs6921438 [<i>LOC100132354</i>], rs7043199 [<i>VLDLR-AS1</i>], rs10761741 [<i>JMJD1C</i>], rs6993770 [<i>ZFPM2</i>], and rs114694170 [<i>MEF2C</i>]), VEGF was unrelated to IHD (odds ratio 0.99 per log-transformed pg/mL, 95%CI 0.96-1.02) using inverse variance weighting.
|
28765276 |
2017 |
rs872129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
High YKL-40 levels (>85 ng/ml) and rs872129 were associated with an increased mortality risk of ischemic stroke, but high YKL-40 levels were also inverse related with the risk of incidence of IHD.
|
22937056 |
2012 |
rs1239681664
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
rs138880920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygosity for an ABCA1 mutation (K776N) conferred two- to three-fold risk of IHD in 37 participants in the Copenhagen City Heart study.
|
16226177 |
2005 |
rs2066714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.
|
17951323 |
2008 |
rs2066718
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.
|
17951323 |
2008 |
rs2230808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite this, 5 out of 6 SNPs (V771M, V825I, I883M, E1172D, R1587K) predicted increased risk of IHD.
|
17951323 |
2008 |
rs33918808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A stepwise regression approach identified V771M, I883M, and E1172D as the most important predictors of IHD and additive effects on IHD risk were present for V771M/I883M and I883M/E1172D pairs.
|
17951323 |
2008 |
rs4147929
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Including 288,563 individuals, meta-analyzed odds ratios for ischemic heart disease per one allele <i>ABCA7</i> rs4147929 increase was 1.01 (0.99-1.03).
|
29376091 |
2018 |
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ABCB1 C3435T polymorphism and the risk of ischemic heart disease: a meta-analysis.
|
25118983 |
2014 |
rs72653706
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In 4 studies including 66 831 participants and 13 642 cases with ischemic vascular events, heterozygosity for ABCC6 R1141X did not associate with risk of IHD, myocardial infarction, ICVD, or ischemic stroke.
|
21831958 |
2011 |
rs750249283
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next, we genotyped 10 237 individuals from the Copenhagen City Heart Study for the identified variants and determined the effect on lipid and lipoprotein levels and on risk of myocardial infarction (MI) and ischemic heart disease (IHD). g.-376C>T, g.-311T>A, and Ser630Leu predicted risk of MI in the Copenhagen City Heart Study, with hazard ratios of 2.2 (95% confidence interval: 1.2-4.3), 1.7 (1.0-2.9), and 7.5 (1.9-30), respectively.
|
22155456 |
2012 |
rs1800888
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ADRB2 Thr164Ile is associated with increased blood pressure, increased frequency of hypertension and increased risk of IHD amongst women in the general population.
|
21883537 |
2012 |
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
M235T genotype did not predict systolic or diastolic blood pressure or risk of ischemic heart disease or myocardial infarction in either ethnic group.
|
12805070 |
2003 |
rs699
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
rs4762
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In six large case-control studies, the M235T and T174M angiotensinogen mutations were not consistently associated with increased (or decreased) risk for ischemic heart disease, myocardial infarction, or ischemic cerebrovascular disease.
|
11352695 |
2001 |
rs567798234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several studies identified that polymorphism of AMP deaminase 1 gene (AMPD1), in particular the common C34T variant of this gene was found to benefit patients with heart failure and ischemic heart disease.
|
24431031 |
2014 |
rs12713559
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterzygous carriers of the Arg3531Cys mutation in the general population did not have higher-than-normal plasma cholesterol levels or an increased risk of ischemic heart disease (odds ratio; 1.4; 95 percent confidence interval, 0.2 to 11; P=0.54).
|
9603795 |
1998 |
rs5742904
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The Arg3500Gln mutation in the apolipoprotein B gene, which is responsible for familial defective apolipoprotein B-100 and is present in approximately 1 in 1000 persons in Denmark, causes severe hypercholesterolemia and increases the risk of ischemic heart disease.
|
9603795 |
1998 |
rs12817819
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ATP2B1 rs12817819 A allele is associated with increased risk for RHTN in hypertensive participants with documented CAD or suspected ischemic heart disease.
|
25385345 |
2014 |