| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.080 | GeneticVariation | BEFREE | Previous studies suggested lipoprotein lipase (LPL) Ser447Ter and Asn291Ser polymorphisms were associated with the risk of ischemic heart disease, however, their effects on ischemic stroke were controversial. | 21816453 | 2011 |
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|
0.080 | GeneticVariation | BEFREE | Pairwise combinations of D9N with -219G > T in APOE and N291S and S447X in LPL significantly improved the prediction of IHD (P = 0.05 in women, P = 0.04 in men, P = 0.03 in men, respectively) beyond smoking, diabetes and hypertension, and identified subgroups of individuals (n = 6-94) with highly significant HRs of 1.92-4.35. | 17006673 | 2007 |
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|
0.080 | GeneticVariation | BEFREE | The G188E, D9N, and N291S mutations in LPL increase TG, reduce HDL cholesterol, and increase risk of ischemic heart disease. | 12208477 | 2002 |
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|
0.080 | GeneticVariation | BEFREE | We previously showed that the common Asn291Ser substitution in lipoprotein lipase is associated with elevated plasma triglyceride levels and a 2-fold increase in the risk of ischemic heart disease in women but not men. | 10821816 | 2000 |
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|
0.080 | GeneticVariation | BEFREE | We have examined the risk of IHD in carriers of two common LPL variants, asparagine substitution for aspartic acid at residue 9 (D9N) and serine for asparagine at residue 291 (N291S) in 2708 middle-aged healthy European men, followed for over 6 years. | 10704617 | 2000 |
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|
0.080 | GeneticVariation | BEFREE | One of these, Asn291Ser, was also found to be associated with increased ischemic heart disease in women. | 11127970 | 2000 |
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|
0.080 | GeneticVariation | BEFREE | Accordingly, risk of ischemic heart disease in heterozygous carriers is increased for Gly188Glu carriers; at most, the increase is borderline for Asp9Asn and Asn291Ser carriers; and risk is possibly decreased for Ser447Ter carriers. | 10359734 | 1999 |
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|
0.080 | GeneticVariation | BEFREE | A common substitution (Asn291Ser) in lipoprotein lipase is associated with increased risk of ischemic heart disease. | 9120004 | 1997 |