Gene: BRAF ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057519720
rs1057519720
BRAF
0.010 GeneticVariation BEFREE Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. 24035431

2013
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE We retrospectively identified 31 lung ADCs diagnosed with <i>BRAF</i> V600E mutation by standard molecular sequencing methods and reviewed their clinical characteristics and pathological features. 31234388

2019
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE This implies limiting the number of tissue slides despite the existence of specific and sensitive biomarkers (ALK, ROS1, BRAF V600E, PD-L1) and the obligation to distinguish lung adenocarcinoma (TTF-1 positive) from squamous cell carcinoma (p40 positive). 30268486

2018
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE Activating BRAF(V600E) (Val600Glu) mutations are found in about 1-2% of lung adenocarcinomas, which might provide an opportunity for targeted treatment in these patients. 27080216

2016
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE Further, the optimal therapeutic strategy to block non-V600E BRAF-mutant LA remains unclear. 27834212

2016
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE The advent of effective targeted therapy for BRAF(V600E) -mutant lung adenocarcinomas necessitates further exploration of the unique clinical features and behavior of advanced-stage BRAF-mutant lung adenocarcinomas. 25273224

2015
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE Approximately 2% of lung adenocarcinomas have BRAF (v-Raf murine sarcoma viral oncogene homolog B) mutations, including V600E and other types. 26200454

2015
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE Lung adenocarcinomas showed significantly higher non-p.V600E mutations (86%) than did colorectal cancers (23%) and melanomas (34%). 26386083

2015
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE The activating BRAF mutation p.V600E has been identified in many cancers, including colon and lung adenocarcinomas, papillary thyroid cancer, malignant melanoma, and hairy cell leukemia (HCL). 25583765

2015
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE Among the 204 lung ADCs tested, 11 cases (5.4%) carried HER2 exon 20 insertions and 4 cases (2.0%) had BRAF V600E mutation. 26102513

2015
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE BRAF V600E-mutated lung adenocarcinoma with metastases to the brain responding to treatment with vemurafenib. 24888229

2014
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE IHC using the VE1 clone and FLEX linker is a specific method for the detection BRAF V600E and may be an alternative to molecular biology for the detection of mutations in lung adenocarcinomas. 23927882

2013
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE This study compared the specificity and sensitivity of IHC with other methods for the detection of BRAF(V600E) in primary lung adenocarcinoma. 23131393

2013
dbSNP: rs121913377
rs121913377
BRAF
0.100 GeneticVariation BEFREE The histopathology of BRAF-V600E-mutated lung adenocarcinoma. 18636014

2008
dbSNP: rs121913351
rs121913351
BRAF
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913351
rs121913351
BRAF
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913351
rs121913351
BRAF
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913355
rs121913355
BRAF
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913355
rs121913355
BRAF
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913355
rs121913355
BRAF
A 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913357
rs121913357
BRAF
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913361
rs121913361
BRAF
T 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913361
rs121913361
BRAF
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913364
rs121913364
BRAF
C 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016
dbSNP: rs121913365
rs121913365
BRAF
G 0.700 GeneticVariation CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011

2016