rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
These findings suggest that the BRAF(V600E) mutation can be detected using a PNA clamp real-time PCR in the blood of PTC patients with lung metastasis.
|
25837167 |
2015 |
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
NK cell frequencies were significantly enhanced by PLX4720 specifically in the lungs of mice with BRAF(V600E) lung metastases.
|
25351955 |
2014 |
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
B-Raf(V600E) cells in which either B-Raf(V600E) or TSP-1 were knocked down were implanted orthotopically into the thyroids of immunocompromised mice, resulting in significant reduction in tumor size and fewer pulmonary metastases from the primary carcinoma as compared with the control cells.
|
20498063 |
2010 |
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Results indicated that knockdown of mutant (V600E)B-Raf inhibited melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo.
|
17575149 |
2007 |
rs113488022
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
rs121913377
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Here, we investigated the role played by (V600E)B-Raf in melanoma metastasis and showed that targeting this signaling cascade significantly reduces lung metastases.
|
16912199 |
2006 |
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Oncogenic L858R mutation of human epidermal growth factor receptor (EGFR) confers constitutive activation to the kinase and is frequently observed in the pathological process of metastatic lung cancer.
|
27643705 |
2016 |
rs1057519847
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
rs1057519848
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
rs121434568
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was a significant difference in newly development of lung metastasis between patients with exon 19 deletion and those with L858R mutation (41.4% vs. 6.3%, p=0.02).PPS was 8.9 months (95% CI, 7.4-10.4).
|
24309368 |
2014 |
rs121434569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T790M detection was associated with higher number of new progressing sites (P = .04), liver progression (P = .002), and a lower frequency of lung metastases (P = .027).
|
31601525 |
2020 |
rs3217992
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, the GA and AA genotypes of rs3217992 in CDKN2A might indicate higher stage and increased risk of lung metastasis of osteosarcoma, resulting in worse prognosis.
|
30774116 |
2019 |
rs201701502
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Although Forced expression of DDR2 and its mutant (T681I) led to induce SQCC cell invasion in vitro, only wild type DDR2 enhanced lung metastasis in an animal model.
|
28676216 |
2017 |
rs121909222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Accordingly, following tail vein injection, both Pten(∆):p53(R270H) spindle and PDA tumor cells induced lung metastases and morbidity significantly faster than Pten(∆):p53(∆) double-deletion cells, and this was associated with the ability of Pten(∆):p53(R270H) tumor cells to upregulate E-cadherin expression in lung metastases.
|
26781438 |
2016 |
rs1989839
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs1989839C/T is also associated with the Enneking stage of osteosarcoma and risk of lung metastasis.
|
27880743 |
2016 |
rs754533102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
By introduction of gene Msurvivin T34A in combination with chemotherapies in the treatment of lung metastasis tumor, it could greatly reduce systemic toxicity as well as improved the anti-tumor efficiency.
|
24582554 |
2014 |
rs1430452530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |
rs762959475
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show that loss of HIF-1α or PLOD2 expression disrupts collagen modification, cell migration, and pulmonary metastasis (but not primary tumor growth) in allograft and autochthonous LSL-Kras(G12D/+); Trp53(fl/fl) murine sarcoma models.
|
23906982 |
2013 |