Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs137852769
rs137852769
0.020 GeneticVariation BEFREE Neither maternal nor fetal heterozygosity for the E474Q mutation is a relevant factor of HELLP syndrome. 17313315

2007

dbSNP: rs137852769
rs137852769
0.020 GeneticVariation BEFREE While carrying fetuses with the Glu474Gln mutation, 79 percent of the heterozygous mothers had fatty liver of pregnancy or the HELLP syndrome. 10352164

1999

dbSNP: rs1137100
rs1137100
0.010 GeneticVariation BEFREE However the LEPR c.326A>G AG genotype was twice more frequent and the (AG AG GG AG) haplotype was three times more frequent in HELLP syndrome patients. 20149225

2010

dbSNP: rs56149945
rs56149945
0.010 GeneticVariation BEFREE The BclI, N363S, and ER22/23EK polymorphisms of the GR gene were determined in 300 healthy pregnant women, 150 pregnant women with severe preeclampsia including 17 pregnant women with HELLP syndrome. 19336230

2009

dbSNP: rs1188383936
rs1188383936
F2
0.010 GeneticVariation BEFREE As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. 18568463

2008

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE As hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome is one of the most severe forms of pre-eclampsia we aimed to assess the prevalence of the factor V Leiden, the prothrombin 20210G >A mutation and the methylenetetrahydrofolate reductase (MTHFR) 677C >T polymorphism in women with HELLP syndrome and in their fetuses from the same index pregnancy. 18568463

2008

dbSNP: rs4986790
rs4986790
0.010 GeneticVariation BEFREE We determined five common mutations in TLR4 (D299G and T399I) and NOD2 (R702W, G908R and L1007fs) in 340 primiparous women with a history of early-onset preeclampsia, of whom 177 women developed HELLP syndrome and in 113 women with a history of only uneventful pregnancies as controls. 18382655

2008

dbSNP: rs4986791
rs4986791
0.010 GeneticVariation BEFREE We determined five common mutations in TLR4 (D299G and T399I) and NOD2 (R702W, G908R and L1007fs) in 340 primiparous women with a history of early-onset preeclampsia, of whom 177 women developed HELLP syndrome and in 113 women with a history of only uneventful pregnancies as controls. 18382655

2008

dbSNP: rs771184127
rs771184127
0.010 GeneticVariation BEFREE We determined five common mutations in TLR4 (D299G and T399I) and NOD2 (R702W, G908R and L1007fs) in 340 primiparous women with a history of early-onset preeclampsia, of whom 177 women developed HELLP syndrome and in 113 women with a history of only uneventful pregnancies as controls. 18382655

2008

dbSNP: rs268
rs268
LPL
0.010 GeneticVariation BEFREE Between a small group of patients with nulliparous HELLP syndrome (a variant of severe preeclampsia: hemolysis, elevated liver enzyme, low platelets) patients (n=12) and control subjects, there was a significant difference in the prevalence of the Asn291Ser mutation (16.7% versus 3.0%, P=0.01). 11711487

2001

dbSNP: rs6025
rs6025
F5
0.010 GeneticVariation BEFREE We report on two patients with HELLP syndrome who were found to be heterozygous for factor V R506Q mutation, leading to activated protein C resistance. 8616100

1996