rs17109512
|
|
|
0.800 |
GeneticVariation |
GWASDB |
We carried out a genome-wide association study of serum aspartate aminotransferase (AST) activity in 866 Amish participants of the Heredity and Phenotype Intervention Heart Study and identified significant association of AST activity with a cluster of single nucleotide polymorphisms located on chromosome 10q24.1 (peak association was rs17109512; P=2.80E-14), in the vicinity of GOT1, the gene encoding cytosolic AST (cAST).
|
21900944 |
2011 |
rs17109512
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
We carried out a genome-wide association study of serum aspartate aminotransferase (AST) activity in 866 Amish participants of the Heredity and Phenotype Intervention Heart Study and identified significant association of AST activity with a cluster of single nucleotide polymorphisms located on chromosome 10q24.1 (peak association was rs17109512; P=2.80E-14), in the vicinity of GOT1, the gene encoding cytosolic AST (cAST).
|
21900944 |
2011 |
rs10272006
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.
|
31311600 |
2019 |
rs11066280
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
|
30718733 |
2019 |
rs117983281
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs118107800
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs11820744
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.
|
31311600 |
2019 |
rs12231737
|
|
T |
0.700 |
GeneticVariation |
GWASCAT |
The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits.
|
30718733 |
2019 |
rs12580745
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs12803802
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs137866734
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs138424361
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs139271658
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.
|
31311600 |
2019 |
rs147627531
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs17342773
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs17835714
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-Wide Association Study Identifies Loci for Liver Enzyme Concentrations in Mexican Americans: The GUARDIAN Consortium.
|
31219225 |
2019 |
rs191610380
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs2371605
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs319991
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs34173
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs3747207
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |
rs4823173
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
In the PNPLA3 gene, rs4823173 (P = 3.44 × 10<sup>-10</sup> ), rs2896019 (P = 7.29 × 10<sup>-9</sup> ), and rs2281135 (P = 8.73 × 10<sup>-9</sup> ) were significantly associated with AST levels.
|
31219225 |
2019 |
rs62141163
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network.
|
31311600 |
2019 |
rs671
|
|
A |
0.700 |
GeneticVariation |
GWASCAT |
Moreover, 9 missense variants were newly identified, of which we identified new associations between a common population-specific missense variant, rs671 (p.Glu457Lys) of ALDH2, and two traits including aspartate aminotransferase (P = 5.20 × 10<sup>-13</sup>) and alanine aminotransferase (P = 4.98 × 10<sup>-8</sup>).
|
30718733 |
2019 |
rs686288
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
|
30589442 |
2019 |