Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1131691003
rs1131691003
A 0.700 CausalMutation CLINVAR

dbSNP: rs1131691042
rs1131691042
T 0.700 CausalMutation CLINVAR

dbSNP: rs11540652
rs11540652
T 0.700 CausalMutation CLINVAR

dbSNP: rs28934576
rs28934576
T 0.700 CausalMutation CLINVAR

dbSNP: rs28934578
rs28934578
T 0.700 CausalMutation CLINVAR

dbSNP: rs55832599
rs55832599
A 0.700 GeneticVariation CLINVAR

dbSNP: rs863223301
rs863223301
GCCATGGC 0.700 CausalMutation CLINVAR

dbSNP: rs221634
rs221634
0.010 GeneticVariation BEFREE We found genotype frequencies in rs314276 and rs221634 were significantly correlated with girls with CPP; while the C allele frequency in rs314276 showed the dominant trait. 28525351

2017

dbSNP: rs314276
rs314276
0.010 GeneticVariation BEFREE Our results demonstrate that the genotype of rs314276 in LIN28B is associated with girls with CPP, carrying dominant trait in the C allele. 28525351

2017

dbSNP: rs350132
rs350132
0.010 GeneticVariation BEFREE A missense change c.1091T>A, and an intron variant c.738+64G>T showed significantly higher allele frequencies in CPP patients than in controls (c.1091T>A: 30.7% vs. 22.2%, P = 0.031; c.738+64G>T: 45.6% vs. 35.9%, P = 0.023). 27914139

2017

dbSNP: rs201617046
rs201617046
0.010 GeneticVariation BEFREE The subgroup with p.G145S showed a significantly higher level of peak luteinizing hormone than the subgroup without p.G145S in girls with CPP. 23585209

2013

dbSNP: rs4680
rs4680
0.010 GeneticVariation BEFREE No association was found between CPP phenotypes (incidence, intensity, and duration) and different rs4680 genotypes. 23566343

2013

dbSNP: rs118000887
rs118000887
0.010 GeneticVariation BEFREE In vitro studies revealed that the rare LIN28B p.H199R variant identified in a girl with CPP does not affect the Lin28B function in the regulation of let-7 expression. 22964795

2012

dbSNP: rs773378963
rs773378963
0.010 GeneticVariation BEFREE The p.A63P variant was identified in a girl with CPP, and p.A449S in a girl with CDGP. 23329188

2012

dbSNP: rs192636495
rs192636495
0.010 GeneticVariation BEFREE Although two of them were novel, those polymorphisms could not lead to amino acid changes. p.P110T was detected less frequently in CPP patients than in the controls (P = 0.022). 20631455

2010

dbSNP: rs201073751
rs201073751
0.010 GeneticVariation BEFREE The p.H90D mutation was identified in the homozygous state in two unrelated girls with CPP. 20237166

2010

dbSNP: rs587777843
rs587777843
0.010 GeneticVariation BEFREE The p.P74S mutation was identified in the heterozygous state in a boy who developed CPP at 1 yr of age. 20237166

2010