Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1463038513
rs1463038513
APC
0.040 GeneticVariation BEFREE Among the genetic defects associated with CRC, the APC I1307K mutation has been detected nearly exclusively in individuals of Ashkenazi Jewish (AJ) origin, occurring in 6%-7% of the AJ general population and in 10%-28% of AJ with a either a personal or family history of CRC or adenomatous polyps. 11354631

2001

dbSNP: rs1801155
rs1801155
APC
0.040 GeneticVariation BEFREE Among the genetic defects associated with CRC, the APC I1307K mutation has been detected nearly exclusively in individuals of Ashkenazi Jewish (AJ) origin, occurring in 6%-7% of the AJ general population and in 10%-28% of AJ with a either a personal or family history of CRC or adenomatous polyps. 11354631

2001

dbSNP: rs34612342
rs34612342
0.020 GeneticVariation BEFREE Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328). 15236166

2004

dbSNP: rs770649674
rs770649674
APC
0.010 GeneticVariation BEFREE Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328). 15236166

2004

dbSNP: rs36053993
rs36053993
0.020 GeneticVariation BEFREE Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328). 15236166

2004

dbSNP: rs587782868
rs587782868
APC
0.010 GeneticVariation BEFREE Biallelic mutations for Y165C and/or G382D were not found in any of those undergoing screening colonoscopy with 0-3 polyps (n = 400), in those APC-negative patients with <20 adenomatous polyps (n = 26), or in those with CRC who were older than 50 years (n = 328). 15236166

2004

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE Findings from six studies of MTHFR C677T and adenomatous polyps are inconsistent. 14977639

2004

dbSNP: rs777919630
rs777919630
CBS
0.010 GeneticVariation BEFREE Findings from six studies of MTHFR C677T and adenomatous polyps are inconsistent. 14977639

2004

dbSNP: rs13181
rs13181
0.010 GeneticVariation BEFREE In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H). 16284370

2005

dbSNP: rs17655
rs17655
0.010 GeneticVariation BEFREE In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H). 16284370

2005

dbSNP: rs1799793
rs1799793
0.010 GeneticVariation BEFREE In a Minnesota-based case-control study of cases with only adenomatous polyps (n = 384), only hyperplastic polyps (n = 191), or both types of polyps (n = 119) versus polyp-free controls (n = 601), we investigated the role of polymorphisms in the DNA repair genes O(6)-methylguanine methyltransferase (MGMT; p.L84F and p.I143V), XPD (p.D312N and p.K751Q), and XPG (p.D1104H). 16284370

2005

dbSNP: rs1801166
rs1801166
APC
0.020 GeneticVariation BEFREE In all, E1317Q was identified in two of 182 patients with adenomatous polyps (1.1%) and in two of 235 controls (0.8%) (p = 0.59). 12537656

2002

dbSNP: rs1800470
rs1800470
0.010 GeneticVariation BEFREE No overall association was seen between the L10P polymorphism and risk of colorectal adenomatous polyps. 15020570

2004

dbSNP: rs1463038513
rs1463038513
APC
0.040 GeneticVariation BEFREE Prevalence of adenomatous polyps in the pathology specimens of the study participants, stratified by their APC I1307K polymorphism status, was studied in 900 consecutive cases of colorectal cancer diagnosed in northern Israel between 1998 and 2002, within the framework of a population-based, case-controlled study (MECC Study). 16228836

2005

dbSNP: rs1801155
rs1801155
APC
0.040 GeneticVariation BEFREE Prevalence of adenomatous polyps in the pathology specimens of the study participants, stratified by their APC I1307K polymorphism status, was studied in 900 consecutive cases of colorectal cancer diagnosed in northern Israel between 1998 and 2002, within the framework of a population-based, case-controlled study (MECC Study). 16228836

2005

dbSNP: rs6983267
rs6983267
0.010 GeneticVariation BEFREE Serum CCAT2 and HULC were upregulated in CRC and AP patients versus controls and discriminated these groups by ROC analysis. rs6983267 GG and rs7763881 AA patients demonstrated higher serum CCAT2 and HULC compared with GT/TT and AC, respectively. rs6983267 and serum HULC predicted CRC diagnosis among non-CRC groups (AP + controls) by multivariate analysis. 29176650

2017

dbSNP: rs7763881
rs7763881
0.010 GeneticVariation BEFREE Studied SNPs were not associated with AP susceptibility. rs6983267 GG was associated with increased CRC risk, whereas rs7763881 AC was protective. rs7763881 and rs6983267 CT haplotype was protective. 29176650

2017

dbSNP: rs3219489
rs3219489
0.010 GeneticVariation BEFREE The Q324H variant was negatively associated with the number of adenomatous polyps (OR -5.23). 25822476

2015

dbSNP: rs776197565
rs776197565
APC
0.010 GeneticVariation BEFREE The Q324H variant was negatively associated with the number of adenomatous polyps (OR -5.23). 25822476

2015

dbSNP: rs1801166
rs1801166
APC
0.020 GeneticVariation BEFREE The APC E1317Q variant in adenomatous polyps and colorectal cancers. 14578138

2003

dbSNP: rs368939818
rs368939818
0.010 GeneticVariation BEFREE The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates. 26028103

2015

dbSNP: rs755001634
rs755001634
0.010 GeneticVariation BEFREE The findings suggest that C1561T-GCPII variation may be associated with risk for adenomatous polyp, and vitamin C may modify risk by interacting with the variant gene, its expression product and/or folate substrates. 26028103

2015

dbSNP: rs1463038513
rs1463038513
APC
0.040 GeneticVariation BEFREE The frequency of the APC I1307K mutation is elevated in Ashkenazi Jewish patients with adenomatous polyps, but not hyperplastic polyps. 10938175

2000

dbSNP: rs1801155
rs1801155
APC
0.040 GeneticVariation BEFREE The frequency of the APC I1307K mutation is elevated in Ashkenazi Jewish patients with adenomatous polyps, but not hyperplastic polyps. 10938175

2000

dbSNP: rs1463038513
rs1463038513
APC
0.040 GeneticVariation BEFREE The high frequency of I1307K colorectal cancer patients found in the Ashkenazi Jewish community of Ottawa and the equivalent proportion of carriers and noncarriers who developed adenomatous polyps suggest that in this community, I1307K is associated with a significant predisposition to carcinoma but not adenoma. 11159880

2001