|
rs10509125
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide association study of behavioural and psychiatric features in human prion disease.
|
25897833 |
2015 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts.
|
27203226 |
2016 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
On the other hand, preferential transmission of COMT rs4680 A allele and A-A haplotype (P<0.05) was observed specifically in male IID probands without any behavioral problem.
|
21609749 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele.
|
18384078 |
2008 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.
|
21231925 |
2011 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior.
|
24389396 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
COMT Val158Met genotype as a risk factor for problem behaviors in youth.
|
20643317 |
2010 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis.
|
23799032 |
2013 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis.
|
28608575 |
2018 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders.
|
24708432 |
2014 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages.
|
22070166 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure.
|
22138198 |
2012 |
|
rs4680
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior.
|
21486391 |
2011 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gene-by-environment studies investigating the impact of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and the Brain Derived Neurotrophic Factor (BDNF) Val66Met polymorphisms by life events on mental health and behaviour problems have been inconclusive.
|
27267363 |
2016 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In spite of abundant evidence that Val66Met BDNF polymorphism has an impact on several different neurological or psychiatric disorders, we conclude that a major clinical impact of Val66Met polymorphism as a disease modifier in temporal lobe epilepsy is probably unlikely.
|
19896331 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In humans and knock-in mice with a loss of function BDNF SNP (Val66Met), the functionality of this circuit was altered, resulting in social behavioral changes in human and mice.
|
30992540 |
2019 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (val66met) in the brain derived neurotrophic factor (BDNF) gene has been shown to be a risk factor for a number of psychiatric disorders, including schizophrenia.
|
20957650 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Several polymorphisms in BDNF have been reported and studied in psychiatric disorders but the most frequent is the p.Val66Met (rs6265G > A) single nucleotide polymorphism (SNP), with functional effects on the intracellular trafficking and secretion of the protein.
|
19603419 |
2010 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.
|
29288952 |
2018 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.
|
17217930 |
2007 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies show that the Val(66)Met BDNF polymorphism correlates with various psychiatric disorders, including anxiety, but there are several differences between experimental and clinical studies.
|
24051499 |
2013 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (rs6265) in the human gene, resulting in a valine to methionine substitution in the pro-BDNF protein, was thought to associate with psychiatric disorders and might play roles in the individual difference of cognitive abilities.
|
19424874 |
2009 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Variants in BDNF, in particular the functional Val66Met polymorphism (rs6265), have been found to be associated with a number of psychiatric disorders, cognitive function, and obesity.
|
24708359 |
2015 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of the valine/methionine variant at codon 66 (Val66Met) of brain derived neurotrophic factor (BDNF) has been reported inconsistently across a spectrum of psychiatric disorders.
|
18797396 |
2008 |
|
rs6265
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, considering that these parameters are determinant for protein interactions and, consequently, protein function; the alterations observed throughout the MD analyses may be related to the functional impairment of BDNF upon V66M mutation, as well as its involvement in psychiatric disorders.
|
30998730 |
2019 |