| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | BEFREE | Association between COMT Val158Met and psychiatric disorders: A comprehensive meta-analysis. | 28608575 | 2018 |
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0.100 | GeneticVariation | BEFREE | Further research with larger samples is needed to explore the interactions of the COMT gene rs4680 polymorphism and sex and psychiatric disorders on suicide attempts. | 27203226 | 2016 |
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0.100 | GeneticVariation | BEFREE | A functional polymorphism COMT Val158Met has been associated with psychiatric disorders including suicidal behavior. | 24389396 | 2014 |
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0.100 | GeneticVariation | BEFREE | Polymorphisms of COMT Val158Met and DAT1 3'-UTR VNTR in illicit drug use and drug-related psychiatric disorders. | 24708432 | 2014 |
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0.100 | GeneticVariation | BEFREE | Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. | 23799032 | 2013 |
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0.100 | GeneticVariation | BEFREE | The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages. | 22070166 | 2012 |
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0.100 | GeneticVariation | BEFREE | One of its most widely studied variations comprises a common single nucleotide polymorphism (SNP), a valine-to-methionine substitution at codon 158 (COMT Val158Met), which has been associated with various cognitive phenotypes, psychiatric disorders and changes in brain activation and structure. | 22138198 | 2012 |
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0.100 | GeneticVariation | BEFREE | On the other hand, preferential transmission of COMT rs4680 A allele and A-A haplotype (P<0.05) was observed specifically in male IID probands without any behavioral problem. | 21609749 | 2011 |
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0.100 | GeneticVariation | BEFREE | To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene. | 21231925 | 2011 |
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0.100 | GeneticVariation | BEFREE | It harbors a common functional polymorphism, a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680), that has been associated with psychiatric disorders characterized with an increased risk of suicidal behavior. | 21486391 | 2011 |
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0.100 | GeneticVariation | BEFREE | COMT Val158Met genotype as a risk factor for problem behaviors in youth. | 20643317 | 2010 |
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0.100 | GeneticVariation | BEFREE | The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation and heterogeneity of the associated allele. | 18384078 | 2008 |