Besides displaying abnormal CSF Aβ<sub>42</sub> levels, rs13333659-T carriers were more likely to exhibit a greater longitudinal cognitive decline (<i>p</i> = 0.029, <i>β</i> = 0.097) and hippocampal atrophy (<i>p</i> = 0.029, <i>β</i> = -0.160) in the non-demented elders, especially for the participants who were amyloid-positive at baseline.