Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | BEFREE | Carriage of BDNF Val66Met has been associated with faster cognitive decline and greater hippocampal atrophy in cognitively normal elderly. | 31771052 | 2020 |
||||
|
0.070 | GeneticVariation | BEFREE | Several heritability studies have reported that the Brain Derived Neurotrophic Factor (<i>BDNF</i>) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. | 30333719 | 2018 |
||||
|
0.070 | GeneticVariation | BEFREE | These results suggest that the <i>BDNF</i> Val66Met polymorphism may play an important role in cognitive decline and could be considered as a target for novel AD therapeutics. | 28468845 | 2017 |
||||
|
0.070 | GeneticVariation | BEFREE | Our findings supported the hypothesis that the BDNF Val66Met polymorphism may affect susceptibility to regional WMH volume and such genotype-by-WMH interaction effect is correlated with cognitive decline in non-demented elderly males, in which the Met allele plays a protective role. | 24275008 | 2014 |
||||
|
0.070 | GeneticVariation | BEFREE | We investigated whether a common Val66Met missense polymorphism (rs6265) of the BDNF gene is associated with individual differences in cognitive decline (marked by perceptual speed) in old age. | 24660789 | 2014 |
||||
|
0.070 | GeneticVariation | BEFREE | We aimed to determine the relationship between BDNF Val66Met and beta-amyloid (Aβ) on cognitive decline, hippocampal atrophy, and Aβ accumulation over 36 months in 165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle study. | 23769397 | 2013 |
||||
|
0.070 | GeneticVariation | BEFREE | These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cognitive decline in AD. | 16627933 | 2006 |