Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2075650
rs2075650
TOMM40
G 0.800 GeneticVariation GWASDB A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 23207651

2014
dbSNP: rs2075650
rs2075650
TOMM40
G 0.800 GeneticVariation GWASCAT A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 23207651

2014
dbSNP: rs429358
rs429358
APOE
0.710 GeneticVariation BEFREE Also, we replicated previous reports of GBA coding variants (rs2230288: p.E365K; rs75548401: p.T408M) being associated with greater motor and cognitive decline over time, and an APOE E4 tagging variant (rs429358) being associated with greater cognitive deficits in patients. 31505070

2019
dbSNP: rs4420638
rs4420638
APOC1
0.710 GeneticVariation BEFREE The minor allele of rs4420638 (G) and the minor allele of rs157582 (T) showed associations with lower Mini-mental State Examination score, higher Alzheimer Disease Assessment Scale-cognitive subscale 11 score and smaller entorhinal volume using both baseline and longitudinal measurements, as well as with accelerated cognitive decline. 31760383

2019
dbSNP: rs429358
rs429358
APOE
0.710 GeneticVariation GWASCAT Genetic architecture of age-related cognitive decline in African Americans. 28078323

2017
dbSNP: rs115881343
rs115881343
TOMM40
0.710 GeneticVariation BEFREE We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not. 24468470

2014
dbSNP: rs115881343
rs115881343
TOMM40
0.710 GeneticVariation GWASCAT We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not. 24468470

2014
dbSNP: rs769449
rs769449
APOE
0.710 GeneticVariation BEFREE We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not. 24468470

2014
dbSNP: rs769449
rs769449
APOE
0.710 GeneticVariation GWASCAT We found 2 independent associations among European-Americans in the 19q13.32 region: rs769449 (APOE intron; p = 3.1 × 10(-20)) and rs115881343 (TOMM40 intron; p = 6.6 × 10(-11)). rs769449 was also associated with cognitive decline among African-Americans (p = 0.005), but rs115881343 was not. 24468470

2014
dbSNP: rs4420638
rs4420638
APOC1
0.710 GeneticVariation GWASDB A genome-wide scan for common variants affecting the rate of age-related cognitive decline. 22054870

2012
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR Mutation m.15923A>G in the MT-TT gene causes mild myopathy - case report of an adult-onset phenotype. 30236074

2018
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR CO2-sensitive tRNA modification associated with human mitochondrial disease. 29760464

2018
dbSNP: rs16885997
rs16885997 		0.700 GeneticVariation GWASCAT Genetic architecture of age-related cognitive decline in African Americans. 28078323

2017
dbSNP: rs17641411
rs17641411
GABRA4
0.700 GeneticVariation GWASCAT Genetic architecture of age-related cognitive decline in African Americans. 28078323

2017
dbSNP: rs73643144
rs73643144
TEK
0.700 GeneticVariation GWASCAT Genetic architecture of age-related cognitive decline in African Americans. 28078323

2017
dbSNP: rs1554950703
rs1554950703
HTRA1 ; LOC105378526
G 0.700 CausalMutation CLINVAR Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL. 27164673

2016
dbSNP: rs1554950703
rs1554950703
HTRA1 ; LOC105378526
G 0.700 CausalMutation CLINVAR Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. 26063658

2015
dbSNP: rs1554950703
rs1554950703
HTRA1 ; LOC105378526
G 0.700 CausalMutation CLINVAR A novel HTRA1 exon 2 mutation causes loss of protease activity in a Pakistani CARASIL patient. 25957642

2015
dbSNP: rs1554950703
rs1554950703
HTRA1 ; LOC105378526
G 0.700 CausalMutation CLINVAR A frameshift mutation in HTRA1 expands CARASIL syndrome and peripheral small arterial disease to the Chinese population. 25772074

2015
dbSNP: rs1554950703
rs1554950703
HTRA1 ; LOC105378526
G 0.700 CausalMutation CLINVAR Loss of HtrA1-induced attenuation of TGF-β signaling in fibroblasts might not be the main mechanism of CARASIL pathogenesis. 25770224

2015
dbSNP: rs10073892
rs10073892
SLCO6A1
0.700 GeneticVariation GWASCAT Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study. 24468470

2014
dbSNP: rs7700443
rs7700443 		0.700 GeneticVariation GWASDB A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. 23207651

2014
dbSNP: rs7157599
rs7157599
DEGS2
C 0.700 GeneticVariation GWASDB Genome-wide association study of cognitive decline in schizophrenia. 23732972

2013
dbSNP: rs10512015
rs10512015
ANXA1
0.700 GeneticVariation GWASDB A genome-wide scan for common variants affecting the rate of age-related cognitive decline. 22054870

2012
dbSNP: rs1556424691
rs1556424691
CYTB ; ND6 ; TRNT
G 0.700 CausalMutation CLINVAR New mitochondrial DNA mutations in tRNA associated with three severe encephalopamyopathic phenotypes: neonatal, infantile, and childhood onset. 22638997

2012