Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II. 24103632

2014

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE We conclude that the BDNF Val66Met polymorphism influenced responses to add-on memantine by decreasing depressive symptoms in patients with BP-II. 24103632

2014

dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378

2013

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378

2013

dbSNP: rs6265
rs6265
0.030 GeneticVariation BEFREE We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. 22877924

2012

dbSNP: rs759834365
rs759834365
0.030 GeneticVariation BEFREE We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. 22877924

2012

dbSNP: rs6280
rs6280
0.020 GeneticVariation BEFREE The DRD3 Ser9Gly Polymorphism Predicted Metabolic Change in Drug-Naive Patients With Bipolar II Disorder. 27310943

2016

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. 25744938

2015

dbSNP: rs4680
rs4680
0.020 GeneticVariation BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378

2013

dbSNP: rs6280
rs6280
0.020 GeneticVariation BEFREE We provide initial evidence that the BDNF Val66Met and DRD3 Ser9Gly genotypes interact only in bipolar-II disorder and that bipolar-I and bipolar-II may be genetically distinct. 22877924

2012

dbSNP: rs5443
rs5443
0.010 GeneticVariation BEFREE At baseline, the GNB3 C825T polymorphisms were associated with the triglyceride level (P=0.032) in BP-II patients. 26856249

2017

dbSNP: rs1200746244
rs1200746244
0.010 GeneticVariation BEFREE Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. 25744938

2015

dbSNP: rs1217691063
rs1217691063
0.010 GeneticVariation BEFREE Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. 25744938

2015

dbSNP: rs749437638
rs749437638
0.010 GeneticVariation BEFREE Logistic regression analysis showed a significant interaction effect of the COMT Val158Met Val/Val genotype and the MTHFR C677T C/T + T/T genotype (P = 0.039) for the protective effect on the odds of developing BP-II. 25744938

2015

dbSNP: rs5848
rs5848
0.010 GeneticVariation BEFREE The presence of the polymorphic variant of the rs5848 single nucleotide polymorphism is protective for the development of bipolar I disorder (BD-I) (odds ratio = 0.55, 95% confidence interval: 0.33-0.93; p = 0.024) but not bipolar II disorder (BD-II) (p > 0.05). 24499389

2014

dbSNP: rs893924483
rs893924483
0.010 GeneticVariation BEFREE Logistic regression analysis showed a significant effect of the COMT and the BDNF polymorphisms, and a significant interaction effect for the Val/Val genotypes of the BDNF Val66Met polymorphism and the COMsT Val158Met Val/Met and Met/Met genotypes (P=0.007, 0.048) discriminated between BP-II without AD patients and controls. 23026378

2013

dbSNP: rs956572
rs956572
0.010 GeneticVariation BEFREE Basal intracellular Ca(2+) concentrations ([Ca(2+) ](B) ) and rs956572 genotypes were determined in B lymphoblast cell lines (BLCLs) from bipolar I disorder (BD-I) (n=150), bipolar II disorder (BD-II) (n=65), and major depressive disorder (n=30) patients, and from healthy subjects (n=70). 21320251

2011

dbSNP: rs6484218
rs6484218
0.010 GeneticVariation BEFREE The strongest result was seen for a single nucleotide polymorphism near the adrenomedullin (ADM) gene (rs6484218), with the best-fitting model indicating that the effect was specific to bipolar II disorder. 20713499

2010