|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two of them (rs944289 and rs116909374) are located at 14q13 making that locus an important target of research into the genetic predisposition to PTC.
|
30350351 |
2019 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It was also shown that patient-related factors modify the predisposition to PTC by increasing the risk for rs944289 per year of age, and by enhancing the protective effect of the FOXE1 GGT haplotype in men.
|
28660995 |
2017 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Results of meta-analysis from the previous study and our new data indicated that variants of rs944289 and rs965513 might be the genetic susceptible factors both in Asians and Caucasians.We get the conclusion that mutations of TTF1 and TTF2 are significantly associated with an increasing risk of PTC in Chinese.
|
26356687 |
2015 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In PTC, significant associations were confirmed for rs965513 (p=4.21E-04; OR 1.587 [CI 1.235-2.000]) and rs944289 (p=0.003; OR 1.234 [CI 1.075-1.408]), newly found for rs2439302 (p=0.003; OR 1.266 [CI 1.087-1.493]) and rs1867277 (p=1.17E-04; OR 1.492 [CI 1.235-1.818]), and was not replicated for rs6983267 (p=0.082; OR 1.136 [CI 0.980-1.316]) in this series.
|
25562676 |
2015 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We previously showed that a long noncoding RNA gene, PTCSC3, located close to the variant rs944289 that predisposes to papillary thyroid carcinoma (PTC) might target the S100A4 gene.
|
26274343 |
2015 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, we found that rs944289 confers its risk, for both papillary thyroid carcinoma and follicular thyroid carcinoma when stratified by histological types of TC.
|
25552255 |
2015 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, rs944289</span> was associated with an increased risk of PTC in the Han population of Northern China, but no clear association was observed in either of the tag single nucleotide polymorphisms of NKX2-1.
|
24452548 |
2014 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, Rs965513 [A] and rs944289 [T] are risk factors of PTC.
|
24723258 |
2014 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Four candidate loci, rs965513 (9q22.33), rs944289 (14q13.3), rs966423 (2q35) and rs2439302 (8p12), identified by GWAS for PTC risk were confirmed in a Chinese population.
|
23847140 |
2013 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that SNP rs944289 predisposes to PTC through a previously uncharacterized, long intergenic noncoding RNA gene (PTCSC3) that has the characteristics of a tumor suppressor.
|
22586128 |
2012 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of both rs965513 (p=1.27×10(-4), OR=1.69, 95% CI 1.29 to 2.21) and rs944289 (p=0.0121, OR=1.21, 95% CI 1.04 to 1.39) with the risk of sporadic PTC was confirmed.
|
21730105 |
2011 |
|
rs944289
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of interest, no association was obtained between radiation-related PTC and rs944289 (mhp = 0.17) at 14p13.3 which showed the second strongest association with sporadic PTC in Europeans.
|
20350937 |
2010 |