Gene: CHRNB4 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation BEFREE The data show a statistical association and suggest biological plausibility that the rs6495309T>C polymorphism contributed to increased risks and poor prognosis of both COPD and lung cancer. 23056235

2012
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation BEFREE The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk. 22404340

2012
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation BEFREE However, we identified four novel SNPs (rs2036534C>T, rs667282C>T, rs12910984G>A, and rs6495309T>C) that were associated with significantly increased lung cancer risk and smoking behavior, which were all confirmed in the replication analyses [odds ratios (95% confidence intervals) in the dominant model: 1.39 (1.23-1.57; P = 2.3 x 10(-7)), 1.52 (1.35-1.71; P = 2.0 x 10(-12)), 1.44 (1.28-1.63; P = 2.7 x 10(-9)), and 1.43 (1.27-1.61; P = 2.6 x 10(-9)), respectively]. 19491260

2009
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs6495309 polymorphism might be a risk factor for the development of lung cancer in Chinese. 25288178

2014
dbSNP: rs6495309
rs6495309
CHRNA3 ; CHRNB4
0.740 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009
dbSNP: rs12441998
rs12441998
CHRNB4
0.700 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009
dbSNP: rs12441998
rs12441998
CHRNB4
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs12594247
rs12594247
CHRNB4
0.700 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008
dbSNP: rs12594247
rs12594247
CHRNB4
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs1316971
rs1316971
CHRNB4
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs1316971
rs1316971
CHRNB4
0.700 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009
dbSNP: rs950776
rs950776
CHRNB4
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs11072768
rs11072768
CHRNB4
0.010 GeneticVariation BEFREE This study confirmed both rs6495308 and rs11072768 gene polymorphisms association with smoking behaviors and had an indirect link between gene polymorphisms and lung cancer risk. 26942719

2016
dbSNP: rs1948
rs1948
CHRNB4
0.010 GeneticVariation BEFREE Overall, these finding suggested that rs1948</span>(C > T) and rs8040868(T > C) could be meaningful as genetic markers for lung cancer risk in Chinese Han population. 29416783

2018
dbSNP: rs7178270
rs7178270
CHRNB4
0.010 GeneticVariation BEFREE CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk. 20587604

2010
dbSNP: rs3813565
rs3813565
CHRNB4 ; LOC105370913
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs3813565
rs3813565
CHRNB4 ; LOC105370913
0.700 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009
dbSNP: rs11072793
rs11072793
CHRNB4 ; LOC105370913 ; LOC112268142
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs11638372
rs11638372
CHRNB4 ; LOC112268142
0.700 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009
dbSNP: rs11638372
rs11638372
CHRNB4 ; LOC112268142
0.700 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008
dbSNP: rs11638372
rs11638372
CHRNB4 ; LOC112268142
0.700 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012
dbSNP: rs11638372
rs11638372
CHRNB4 ; LOC112268142
0.700 GeneticVariation GWASDB Lung cancer susceptibility locus at 5p15.33. 18978790

2008
dbSNP: rs1996371
rs1996371
CHRNB4 ; LOC112268142
0.700 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008