Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE BRAF- and MEK-targeted therapies are effective in BRAF V600E/K metastatic melanoma and lung cancers; however, responses are short-lived due to emergence of resistance. 31744895

2020

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Accordingly, the combination of MEK inhibitor with EGFR inhibitor was effective at shrinking tumors in mouse model of BRAF non-V600E mutant lung cancer. 29348459

2018

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Success of this design of clinical trials and practice was first demonstrated in EGFR inhibitor trials in lung cancer and has since been incorporated into subsequent targeted therapy trials including ALK-, ROS1-, and BRAF V600E-targeted therapies. 28786099

2017

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE As discoveries of targeted drugs for stage IV patients accelerate-prompting routine testing for ALK, ROS1, RET, BRAF V600E, and HER2, among others-there is an argument that all lung cancers should be genotyped for the purpose of classification, regardless of stage of disease. 26215190

2015

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Although oncogenic KRAS mutations are frequent, BRAF mutations (BRAF(V600E)) are found in 3% of human non-small cell lung cancers. 23825589

2013

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE BRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear. 24035431

2013

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE Colorectal and lung cancers associated with the BRAF V600E mutation often demonstrated mucinous morphology. 23370429

2013

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE BRAF V600E protein was expressed in BM of 42/76 (55.3%) melanomas, 1/15 (6.7%) ovarian cancers, 4/72 (5.5%) colorectal cancers, 1/355 (0.3%) lung cancers, 2/6 thyroid cancers and 1/2 choriocarcinomas. 22012135

2012

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE The incidence of BRAF mutations other than V600E is significantly higher in lung cancer than in melanoma. 21483012

2011

dbSNP: rs113488022
rs113488022
0.100 GeneticVariation BEFREE V599E BRAF mutation was uncommon in Japanese lung cancer. 16376942

2006