|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, no association between the MnSOD Val(16)Ala polymorphism and lung cancer was detected among ETS-exposed individuals (OR 1.6, P = 0.147), although the lung cancer group had significantly lower MnSOD activity than the chronic or passive smoker groups (P = 0.03).
|
23928928 |
2014 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Subgroup analysis by ethnicity suggested that SOD2 C47T polymorphism was significantly associated with lung cancer</span> in both East Asians and Caucasians.
|
23990443 |
2014 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Although the majority of evidence supports associations between the SOD2 Ala16Val SNP and diseases such as breast, prostate and lung cancers, diabetes and cardiovascular disease, the presence of the SOD2 Ala16Val SNP confers only a small, clinically insignificant reduction (if any) in the risk of these diseases.
|
22525041 |
2012 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A review was conducted of 136 patients treated with radiation therapy for lung cancer between 2001 and 2007, and who had prior genotyping of functional single-nucleotide polymorphisms in oxidative stress genes including superoxide dismutase 2 (SOD2; rs4880) and methylene tetrahydrofolate reductase (MTHFR; rs1801131, rs1801133).
|
22144047 |
2012 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer.
|
18258609 |
2008 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Studies focused on GSTT1 null and SOD2 Ala16Val polymorphisms gave conflicting results, while promising results came from studies on alpha1-antitrypsin in asbestosis and MPO in lung cancer.
|
18420450 |
2008 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The common Val16Ala MnSOD polymorphism and C-T substitution in the promoter region of the catalase gene do not confer increased or reduced risk of lung cancer in Chinese in Hong Kong.
|
17409931 |
2006 |
|
rs4880
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We therefore examined the association between single nucleotide polymorphisms (SNPs) in four genes (AKR1C3-Gln5His, NQO1-Pro187Ser, MnSOD-Val16Ala and OGG1-Ser326Cys) that play a role in the generation, prevention or repair of oxidative damage and lung cancer risk in a population-based, case-control study of 119 cases and 113 controls in Xuan Wei, China.
|
15284179 |
2004 |