Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6). 29110844

2017

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers. 27072204

2016

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE The association between rs8034191 and lung cancer risk was significant using multiple genetic models, suggesting that rs8034191 is a risk factor for lung cancer. 25854352

2015

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE In conclusion, this meta-analysis demonstrated that the two common variations (rs8034191 and rs1051730) at 15q25 are a risk factor associated with increased LC susceptibility, but these associations vary in different ethnic populations. 24254305

2014

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE There was no overall association between variant rs8034191 and lung cancer risk under the allele frequency model (OR = 1.03, 95 % CI = 0.93-1.13, P heterogeneity = 0.522). 25074529

2014

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE However, no significant association was found between rs8034191T/C and LC risk. 23359026

2013

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE Here, the authors apply a novel method for mediation analysis, allowing for gene-environment interaction, to a lung cancer case-control study (1992-2004) conducted at Massachusetts General Hospital using 2 single nucleotide polymorphisms, rs8034191 and rs1051730, on 15q25.1. 22306564

2012

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians. 22701590

2012

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE Diplotype analysis of rs3841324 with either rs16969968 or rs8034191 showed that these polymorphisms influenced the lung cancer risk independently. 22028403

2011

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE We found that 2 risk single nucleotide polymorphisms reported in the lung cancer GWA studies-rs8034191: A>G and rs1051730: G>A, located in this 15q24-25.1 region-were not associated with risk of pancreatic cancer. 21697764

2011

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE However, rs7452888 (6q27) was identified as a possible candidate SNP to influence lung cancer survival, while stratified analysis hinted at a possible role for rs8034191</span>, rs16969968 (15q25.1) and rs4324798 (6p22.1) in influencing survival time in lun</span>g cancer patients who were never-smokers, based on a small sample. 21750227

2011

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE We evaluated five of the top candidate SNPs (rs402710, rs2736100, rs4324798, rs16969968, and rs8034191) for their effects on lung cancer risk and overall survival. 20056643

2010

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE Similarly, neither CHRNA3 rs8034191 nor rs1051730 were associated with lung cancer risk. 20068085

2010

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE The goal of this study was to determine whether recently identified genetic variation in 3 SNPs (rs1051730, rs931794, rs8034191) on chromosome 15q25.1 contributes to risk of lung cancer in African Americans. 19641473

2009

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation GWASDB A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk. 19654303

2009

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE A meta-analysis provided increased support that variation at 15q25.1 (rs8034191; P = 3.24 x 10(-26)), 5p15.33 (rs4975616; P = 2.99 x 10(-9)), and 6p21.33 (rs3117582; P = 4.46 x 10(-10)) influences lung cancer risk. 19654303

2009

dbSNP: rs8034191
rs8034191
C 0.800 GeneticVariation GWASDB A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. 18385738

2008

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation GWASDB Lung cancer susceptibility locus at 5p15.33. 18978790

2008

dbSNP: rs8034191
rs8034191
G 0.800 GeneticVariation GWASDB Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. 18385676

2008

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation BEFREE The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. 18780872

2008

dbSNP: rs8034191
rs8034191
0.800 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008

dbSNP: rs8034191
rs8034191
G 0.800 GeneticVariation GWASDB The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. 18780872

2008