|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We examined the clinicopathological and prognostic value of rs401681 variants in lung cancer.
|
29033187 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The rs401681 polymorphism was significantly associated with a decreased risk of lung cancer, bladder cancer, and basal cell carcinoma in Asians and in hospital-based studies.
|
29254260 |
2017 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
After adjusting for known risk loci, rs2736100 and rs401681, we identified a new, independent lung cancer susceptibility variant in LPCAT1: rs139852726 (OR = 0.46, P = 4.73×10(-9)), and three new adenocarcinoma risk variants in TERT: rs61748181 (OR = 0.53, P = 2.64×10(-6)), rs112290073 (OR = 1.85, P = 1.27×10(-5)), rs138895564 (OR = 2.16, P = 2.06×10(-5); among young cases, OR = 3.77, P = 8.41×10(-4)).
|
26590902 |
2016 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In the genetic model analysis, we found rs402710 and rs401681 were associated with decreased lung cancer risk.
|
25526467 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, our study indicated that the CLPTM1L - rs401681 (G>A) polymorphism was significantly associated with decreased lung cancer risk, especially among European populations.
|
24634236 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings demonstrated that rs402710 and rs401681 are risk-conferring factors for the development of lung cancer.
|
24907075 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
No association was found between CLPTM1L-rs401681 and lung cancer risk.
|
24861918 |
2014 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We genotyped rs2736100 (TERT) and rs401681 (CLPTM1L) SNPs in a case-control study with 399 lung cancer cases and 466 controls form Taiyuan, China.
|
23433592 |
2013 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our findings provide further evidence supporting rs401681 as a genetic variant associated with the risk of lung cancer.
|
24386361 |
2013 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The results from our case-control study and meta-analysis provide convincing evidence that rs401681 is significantly associated with lung cancer risk.
|
23653681 |
2013 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk.
|
22404340 |
2012 |
|
rs401681
|
|
|
0.800 |
GeneticVariation |
BEFREE |
We tested rs401681 for association with 16 additional cancer types in over 30,000 cancer cases and 45,000 controls and found association with lung cancer (OR = 1.15, P = 7.2 x 10(-8)) and urinary bladder, prostate and cervix cancer (ORs = 1.07-1.31, all P < 4 x 10(-4)).
|
19151717 |
2009 |
|
rs401681
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Overall, the findings from our replication study and meta-analysis demonstrated that CLPTM1L gene rs31489 is significantly associated with lung cancer.
|
25422207 |
2014 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
Overall, significantly elevated LC risk was associated with rs2736100, rs401681, rs402710, and rs31489 polymorphisms when all studies were pooled into the meta-analysis.
|
24615522 |
2014 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
In conclusion, this meta-analysis suggested that CLPTM1L rs31489 was a potential biomarker for lung cancer risk in Caucasians.
|
24535780 |
2014 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
The rs31489 variant on 5p15.33 is associated with bronchial obstruction, presence and severity of emphysema, and lung cancer.
|
21622582 |
2011 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
BEFREE |
SNP rs31489 showed the strongest evidence of familial lung cancer association on 5p15.33 (P = 2 x 10(-4); odds ratio, 0.57; 95% confidence interval, 0.42-0.77), whereas rs3117582 showed a weak association on 6p21.33 (P = 0.09; odds ratio, 1.47; 95% confidence interval, 0.94-2.31).
|
20142248 |
2010 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
rs31489
|
|
|
0.750 |
GeneticVariation |
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
rs402710
|
|
|
0.100 |
GeneticVariation |
BEFREE |
By analyzing 1000 genomes data for East Asian, we identified only one SNP in nearby region, rs402710, in high linkage disequilibrium with rs401681, which was also associated with lung cancer.
|
29939218 |
2018 |