rs10490924
|
|
|
0.900 |
GeneticVariation |
GWASDB |
HTRA1 promoter polymorphism in wet age-related macular degeneration.
|
17053108 |
2006 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The AMD cases possessing the LOC387715 (rs10490924) variant may have a higher risk of neovascular AMD.
|
17210853 |
2007 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two SNPs generated highly significant allelic associations with PCV (rs10490924, P = 5.7 x 10(-6); rs11200638, P = 5.2 x 10(-6)) and AMD (rs10490924, P = 1.4 x 10(-6); rs11200638, P = 3.4 x 10(-7)).
|
17692272 |
2007 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We propose that rs10490924 represents a major susceptibility variant for AMD at 10q26.
|
17884985 |
2007 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To examine phenotypes of age-related macular degeneration (AMD) patients with the LOC387715 variant (T allele at rs10490924, A69S).
|
18061132 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10</span>490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using DNA extracted from venous blood of 876 white participants in AREDS categories 3 and 4, that is, those considered to be at high risk for progression to advanced AMD, the authors genotyped for the single nucleotide polymorphisms in the CFH (Y402H, rs1061170) and LOC387715/ARMS2 (A69S, rs10490924) genes.
|
18423869 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD).
|
18436811 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped three SNPs, rs1061170 (exon 9, CFH), rs11200638 (HTRA1 promoter, -512 bp), and rs10490924 (6.6 kb upstream of HTRA1 in LOC387715/ARMS2) in 333 cases with advanced AMD (choroidal neovascularization [CNV] and geographic atrophy) and 171 age-matched examined controls.
|
18682806 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Significant associations were detected for exudative AMD with SNPs rs10490924:G>T in LOC387715 (A69S), and rs11200638:G>A in the promoter of HTRA1.
|
18682812 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs10490924 polymorphism, the major determinant of the 10q26 association with ARMD, determines the A69S substitution in the LOC387715/ARMS2 gene.
|
18688167 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Homozygotes for the T allele of rs10490924 had an odds ratio (OR) of 8.6, with a 95% confidence interval (CI) of 3.5-20.8, and homozygotes for the A allele of rs11200638 had an OR of 10.7, with a 95% CI of 3.2-35.7, for having AMD (p<0.00001).
|
19065273 |
2008 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs10490924 on chromosome 10 in exon 1 of the ARMS2 gene showed a highly significant association with an odds ratio (OR) of 3.2 (95% CI 2.4-4.2) for the risk allele and rs11200638 located in the proximal promoter region of HTRA1 showed a higher significant association with an OR of 3.4 (95% CI 2.5-4.6) with our AMD cases.
|
19259132 |
2009 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
One haplotype, which contained the T allele of the rs10490924 (A69S) and the variant of de1443ins54 polymorphism, had an odds ratio of 3.14 (P = 7.8 x 10(-6)) for AMD and 2.00 (P = .0058) for PCV.
|
19268887 |
2009 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The specific functional role of ARMS2-rs10490924 remains as yet unknown, but it appears to mainly affect the progression to late AMD stages.
|
19797206 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The six high-risk alleles all showed a statistically significant association with AMD (the most significant SNP was rs10490924 [P < or = 3.31 x 10(-5), OR = 1.86]; the least significant SNP was rs932275 [P < or = 9.15 x 10(-5), OR = 1.78]).
|
19933195 |
2010 |
rs3750848
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Purpose.To determine the relationship of six genetic variants (rs10490924, rs3750848, del443ins54, rs3793917, rs11200638, and rs932275) localized to the ARMS2-HTRA1 region of chromosome 10, region q26, as risk factors for age-related macular degeneration (AMD), to define the haplotype structure of these six loci, and to confirm their genetic association with the disease.Methods.
|
19933195 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The lack of functional effects of the 3'UTR indel, the amino acid substitution of rs10490924 (A69S), and strong LD between them suggest that A69S, not the indel, is the variant that confers risk of AMD.
|
20182747 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).
|
20385826 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped two SNPs that are located in the LOC387715 locus (rs10490924) and HTRA1 (rs11200638) in 137 cases of exudative AMD and 187 controls.
|
20456446 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The I62V and A69S polymorphisms were associated with all three subtypes: tAMD (P = 3.74 × 10(-18) and 1.</span>37 × 10(-35), respectively), PCV (P = 3.18 × 10(-19) and 3.96 × 10(-18), respectively), and RAP (P = 0.034 and 2.49 × 10(-18), respectively).
|
20574013 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Multiple studies demonstrate a strong association between three variants at chromosome 10q26 - rs10490924, del443ins54, and rs11200638 - near the age-related maculopathy susceptibility 2 (ARMS2) and high-temperature requirement factor A1 (HTRA1) genes with susceptibility to age-related macular degeneration (AMD).
|
20664794 |
2010 |
rs10490924
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A total of 1,080 patients with exudative AMD and 406 controls were recruited and genotyped for Y402H of complement factor H (CFH), rs10490924 of age-related maculopathy susceptibility 2 (ARMS2), and R102G of the C3 gene.
|
20664795 |
2010 |