|
rs1064583
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs1120638
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine the impact of <i>HTRA1</i> rs1120638, <i>TIMP3</i> rs9621532, <i>VEGFA</i> rs833068, <i>CFI</i> rs10033900, <i>ERCC6</i> rs3793784, and <i>KCTD10</i> rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population.
|
31583032 |
2019 |
|
rs115333865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10<sup>-11</sup>), rs151214675 (RTEL1, p = 3.18 × 10<sup>-8</sup>), rs140250387 (DLGAP1, p = 4.49 × 10<sup>-7</sup>), and rs115333865 (CGRRF1, p = 1.05 × 10<sup>-6</sup>).
|
31367973 |
2019 |
|
rs11671784
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These analyses reported that the SNPs rs11671784 (<i>MIR27A</i>, G/A) and rs2910164 (<i>MIR146A</i>, C/G) were significantly associated with AMD risk.
|
30934838 |
2019 |
|
rs13079080
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, genotyping rs13079080 in an AMD case-control cohort revealed a protective effect of the TT genotype on AMD compared to the CC genotype (p = 0.007, odds ratio = 0.66).
|
31304868 |
2019 |
|
rs140250387
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10<sup>-11</sup>), rs151214675 (RTEL1, p = 3.18 × 10<sup>-8</sup>), rs140250387 (DLGAP1, p = 4.49 × 10<sup>-7</sup>), and rs115333865 (CGRRF1, p = 1.05 × 10<sup>-6</sup>).
|
31367973 |
2019 |
|
rs151214675
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10<sup>-11</sup>), rs151214675 (RTEL1, p = 3.18 × 10<sup>-8</sup>), rs140250387 (DLGAP1, p = 4.49 × 10<sup>-7</sup>), and rs115333865 (CGRRF1, p = 1.05 × 10<sup>-6</sup>).
|
31367973 |
2019 |
|
rs1536304
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, EURs had lower odds of AMD with enhanced copies of rs1536304 (<i>VEGFA</i>) and higher odds with more copy numbers of rs3766404 (<i>CFH</i>).
|
30820144 |
2019 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD.
|
30662836 |
2019 |
|
rs1800630
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD.
|
30662836 |
2019 |
|
rs1927907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association has been discovered between TLR4 rs1927907 polymorphism and AMD susceptibility.
|
31083239 |
2019 |
|
rs1927914
|
|
|
0.010 |
GeneticVariation |
BEFREE |
C-C haplotype was negatively associated with AMD risk (OR = 0.242, 95% CI = 0.121-0.485; OR = 0.242, 95% CI = 0.120-0.488).CC genotype and C allele of rs1927914 were significantly associated with the decreased AMD susceptibility.
|
31083239 |
2019 |
|
rs200437673
|
|
|
0.010 |
GeneticVariation |
BEFREE |
After correcting for multiple testing (n = 37,428), we identified four variants significantly associated with AMD: rs200437673 (LCN9, p = 1.50 × 10<sup>-11</sup>), rs151214675 (RTEL1, p = 3.18 × 10<sup>-8</sup>), rs140250387 (DLGAP1, p = 4.49 × 10<sup>-7</sup>), and rs115333865 (CGRRF1, p = 1.05 × 10<sup>-6</sup>).
|
31367973 |
2019 |
|
rs2588809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs2910164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These analyses reported that the SNPs rs11671784 (<i>MIR27A</i>, G/A) and rs2910164 (<i>MIR146A</i>, C/G) were significantly associated with AMD risk.
|
30934838 |
2019 |
|
rs361525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To study polymorphisms in promotor regions of <i>tumor necrosis factor (TNF)-α TNF-863A/C</i> (rs1800630), <i>TNF-308A/G</i> (rs1800629), and <i>TNF-238A/G</i> (rs361525) in patients with age-related macular degeneration (AMD) and associations of complex <i>TNF-α</i> genotypes with AMD.
|
30662836 |
2019 |
|
rs4351376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs4351379
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>RAD51B</i> (rs8017304 and rs2588809), <i>TRIB1</i> (rs6987702, rs4351379, and rs4351376), <i>COL8A1</i> (rs13095226), and <i>COL10A1</i> (rs1064583) Gene Variants with Predisposition to Age-Related Macular Degeneration.
|
31191752 |
2019 |
|
rs56209061
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study identified two markers, rs11200638 and rs3793784, as risk factors for early and exudative AMD, and one marker, rs56209061, as a protective factor for early and exudative AMD development.
|
31583032 |
2019 |
|
rs768435443
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for a novel complex allele G1961E/L857P causes a childhood-onset cone-rod dystrophy rather than the young-adult-onset macular dystrophy that is associated with G1961E alone.
|
31318848 |
2019 |
|
rs833068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine the impact of <i>HTRA1</i> rs1120638, <i>TIMP3</i> rs9621532, <i>VEGFA</i> rs833068, <i>CFI</i> rs10033900, <i>ERCC6</i> rs3793784, and <i>KCTD10</i> rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population.
|
31583032 |
2019 |
|
rs868349465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two siblings with macular dystrophy carried compound heterozygous EYS variants: c.1299+5_1299+8del and c.6050G>T.
|
31074760 |
2019 |
|
rs1042579
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next generation sequencing (NGS) showed polymorphism in CFH (p.V62I in SCR1) and THBD (p.A473V), already known as pathogenic for C3GN, as well as a mutation in C3 (p.R102G) associated only with age-related macular degeneration (AMD) so far.
|
29592796 |
2018 |
|
rs1195312059
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genomic DNA was analyzed by targeted analysis of the c.133C>T;p.R45W mutation for all RP or macular dystrophy-related genes.
|
30025130 |
2018 |
|
rs1345823874
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The pathogenic mutation S163R in C1QTNF5 causes a disorder known as autosomal dominant late-onset retinal degeneration (L-ORD), characterized by the presence of thick extracellular sub-RPE deposits, similar histopathologically to those found in AMD patients.
|
29721928 |
2018 |