Gene: C3 ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE No interaction was found between rs2230199 and smoking or other AMD loci. 19234341

2009
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE The variant C3-rs2230199 showed no relation with AMD progression. 19797206

2010
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE In contrast, the C3 variants rs2230199 and rs1047286 were not associated with exudative AMD in the studied subjects. 19850835

2010
dbSNP: rs1047286
rs1047286
C3
0.050 GeneticVariation BEFREE In contrast, the C3 variants rs2230199 and rs1047286 were not associated with exudative AMD in the studied subjects. 19850835

2010
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). 19899988

2009
dbSNP: rs2250656
rs2250656
C3
0.020 GeneticVariation BEFREE The G allele of C3 IVS2 rs2250656 may be a significantly protective factor for neovascular AMD in the Chinese population. 19899988

2009
dbSNP: rs10411506
rs10411506
C3
0.010 GeneticVariation BEFREE The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). 19899988

2009
dbSNP: rs163913
rs163913
C3
0.010 GeneticVariation BEFREE The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). 19899988

2009
dbSNP: rs2230205
rs2230205
C3
0.010 GeneticVariation BEFREE The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). 19899988

2009
dbSNP: rs339392
rs339392
C3
0.010 GeneticVariation BEFREE The G allele of the C3 IVS2 rs2250656, but not other tested C3 SNPs of rs2230205, rs10411506, rs2230199, rs339392, and rs163913, was significantly associated with a reduced risk for AMD in the Chinese population (OR 0.605, 95% CI 0.39-0.93, p = 0.023), even after adjusting for age, gender, smoking status, CFH rs1061170, CFB rs4151667, and CFB rs641153 allele status (OR 0.58, 95% CI 0.35-0.96, p = 0.033). 19899988

2009
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASCAT Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation GWASDB Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation GWASCAT Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). 20385826

2010
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASDB Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASCAT Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE For rs2230199, patients with CG and GG genotypes were 1.44 (95% confidence interval (CI): 1.33, 1.56) and 1.88 (95% CI: 1.59, 2.23) times more likely to have AMD than patients with the CC genotype. 21576320

2011
dbSNP: rs1047286
rs1047286
C3
0.050 GeneticVariation BEFREE For rs1047286, GA and AA genotypes had 1.27 (95% CI: 1.15, 1.41) and 1.70 (95% CI: 1.27, 2.11) times higher risk of AMD than did GG genotypes. 21576320

2011
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASDB Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASCAT Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. 21665990

2011
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE However, the risk allele is absent or rare (<1%) in Japanese and Chinese populations, and the association of R102G with AMD has not been reported in Asian populations. 22174912

2011
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASDB Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes. 22705344

2012
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation BEFREE Genotyping was performed for the Y402H variant of CFH, for the L9H, R32Q, and K565E variants of CFB, the E318D variant of C2, the A69S variant of ARMS2, and the R102G variant of C3 in 159 Mexican mestizo patients at advanced stages of AMD, i.e., CARMS (Clinical Age-Related Maculopathy Staging System) grade 4 or 5. 23112567

2012
dbSNP: rs2230199
rs2230199
C3
0.900 GeneticVariation GWASDB Seven new loci associated with age-related macular degeneration. 23455636

2013
dbSNP: rs2230199
rs2230199
C3
C 0.900 GeneticVariation GWASCAT Seven new loci associated with age-related macular degeneration. 23455636

2013