|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
|
27999450 |
2016 |
|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering AMD in a Spanish population.
|
23971975 |
2013 |
|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
|
rs833061
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
However, weak correlations between 10 SNPs (CFH rs1329428 TT genotype, CFH rs3753394 CC genotype and T allele, CFH rs1410996 AA genotype, CFH rs800292 AA genotype, CFH rs800292 A allele, VEGF rs833061 TT genotype and C allele, VEGF rs2010963 CG genotype, VEGFR2 rs1531289 TT genotype, ARMS2 rs10490924 TT genotype, KCTD10 rs238104 GC genotype, rs1531289 T allele and ARMS2 rs10490924 T allele) and AMD were shown.
|
30696427 |
2019 |
|
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The aim of the present study is to carry out a systematic review and an updated meta-analysis in order to summarize the current published studies and to evaluate the associations between four common vascular endothelial growth factor (<i>VEGF</i>) polymorphisms (rs833061, rs1413711, rs3025039, and rs2010963) and AMD risk, also stratifying for AMD subtypes and ethnicity.
|
27999450 |
2016 |
|
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
|
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
The present meta-analyses indicated that there were no significantly associations between VEGF polymorphisms (rs833061, rs1413711, rs2010963) and the risk of AMD, although the association was different for each polymorphism among different populations.
|
22307787 |
2012 |
|
rs2010963
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In our work, we searched for an association between the -460C> (rs833061) and -634G>C (rs2010963) polymorphisms of the VEGF gene and the occurrence of AMD and its dry and wet forms.
|
19761764 |
2009 |
|
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to AMD susceptibility.
|
23761723 |
2013 |
|
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Genotypes of 3 polymorphisms in known AMD susceptibility loci (rs1061170 in complement factor H (CFH), rs11200638 in HTRA1 and rs1413711 in VEGF) were determined.
|
24080590 |
2013 |
|
rs1413711
|
|
|
0.040 |
GeneticVariation |
BEFREE |
We observed a prevalence of homozygosity (TT genotype) of 18.1% for rs1413711 among AMD cases compared with 5.8% among controls (P < 0.002).
|
21881842 |
2012 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Significant associations with AMD risk were showed for rs833061, rs1413711, and rs3025039 polymorphisms but not for rs2010963.
|
27999450 |
2016 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The meta-analysis results based on nine case-control studies with 2427 cases and 2037 controls showed that rs833061 had protective effects on AMD risk (TT vs. CT+CC: OR=0.58, 95% CI=0.41-0.81), whereas rs1413711 (TT vs. CT+CC: OR=1.46, 95% CI=1.10-1.93) and rs3025039 (TT vs. CC: OR=1.87, 95% CI=1.15-3.02; TT vs. CT+CC: OR=2.09, 95% CI=1.30-3.37) represented as risk factors for AMD.
|
24689893 |
2014 |
|
rs3025039
|
|
|
0.030 |
GeneticVariation |
BEFREE |
No association was observed between AMD risk and the variant genotypes of VEGF-A rs2010963 and rs3025039 polymorphisms in different genetic models.
|
23761723 |
2013 |
|
rs2146323
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.
|
27404493 |
2016 |
|
rs699947
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF rs2146323 and rs699947 SNPs have no relationship to exudative AMD formation, and none of these seem to have any effect on anti-VEGF response.
|
27404493 |
2016 |
|
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
No association was found to support the role for the rs833069, rs943080 and rs4711751 variants of or near VEGFA gene in susceptibility to either PCV or neovascular AMD in Han Chinese population.
|
24303777 |
2015 |
|
rs699947
|
|
|
0.020 |
GeneticVariation |
BEFREE |
VEGF A (rs699947 and rs833061) and VEGFR2 (rs2071559) gene polymorphisms are not associated with AMD susceptibility in a Spanish population.
|
23971975 |
2013 |
|
rs2146323
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The VEGF gene polymorphic SNPs at rs699947 and rs2146323 are strong determinants of the anatomic outcome after PDT, but the SNPs studied were not associated with the presence of exudative AMD or with the CNV lesion size or configuration.
|
19896188 |
2010 |
|
rs833069
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Two polymorphisms (rs833069</span> in intron 2 of the VEGF-A gene, rs2071559 in the promoter of the KDR gene) were significantly associated with risk of AMD.
|
20471686 |
2010 |
|
rs833068
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine the impact of <i>HTRA1</i> rs1120638, <i>TIMP3</i> rs9621532, <i>VEGFA</i> rs833068, <i>CFI</i> rs10033900, <i>ERCC6</i> rs3793784, and <i>KCTD10</i> rs56209061 genotypes on the development of age-related macular degeneration (AMD) in the Lithuanian population.
|
31583032 |
2019 |