| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | BEFREE | The meta-analyses showed that the most-studied SNP rs2511989 was not significantly associated with all forms of AMD, neovascular AMD, or PCV in East Asians (P = 0.98, 0.93 and 0.30, respectively) but was associated with AMD in Caucasians (P = 0.04 for all AMD and 0.004 for neovascular AMD). | 25800435 | 2015 |
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|
0.070 | GeneticVariation | BEFREE | The current meta-analysis shows that the SERPING1 rs2511989 polymorphism may have a positive effect on the risk of AMD, especially among Caucasians. | 25352749 | 2014 |
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|
0.070 | GeneticVariation | BEFREE | Our sample size had a statistical power of more than 90% to detect an association of a risk allele with an odds ratio reported in the original studies for rs2511989</span> for developing AMD. | 21526158 | 2011 |
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|
0.070 | GeneticVariation | BEFREE | SERPING1 SNPs rs1005510 and rs2511989 were significantly associated with neovascular AMD in our cohort, with rs1005510 conferring an adverse risk effect (OR 1.49, 95% CI 1.18 to 1.88) and rs2511989 conferring a protective effect (OR 0.73, 95% CI 0.59 to 0.90). | 20606025 | 2010 |
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|
0.070 | GeneticVariation | BEFREE | A previously reported age-related macular degeneration-related risk factor (rs2511989) was forcibly included. | 20161815 | 2010 |
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|
0.070 | GeneticVariation | BEFREE | The seven tag-SNPs were not associated with AMD in the Mayo subjects (p=0.13-0.70) and rs2511989 was also not associated with AMD in the Mayo or AREDS subjects (p=0.44-0.45). | 19169411 | 2009 |
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|
0.070 | GeneticVariation | BEFREE | The odds ratio for age-re</span>lated macular degeneration in rs2511989 G/A heterozygotes compared with wild type G/G homozygotes was 0.63 (95% CI 0.47-0.84). | 18842294 | 2008 |