Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE Nineteen single nucleotide polymorphisms (SNPs) previously associated with AMD, including rs10490924 (<i>ARMS2/HTRA1</i>), rs10737680 (<i>CFH</i>), rs13278062 (<i>TNFRSF10A</i>), rs1864163 (<i>CETP</i>), rs2230199 (<i>C3</i>), rs3130783 (<i>IER3/DDR1</i>), rs334353 (<i>TGFBR1</i>), rs3812111 (<i>COL10A1</i>), rs429608 (<i>C2/CFB</i>), rs4420638 (<i>APOE</i>), rs4698775 (<i>CFI</i>), rs5749482 (<i>TIMP3</i>), rs6795735 (<i>ADAMTS9</i>), rs8017304 (<i>RAD51B</i>), rs8135665 (<i>SLC16A8</i>), rs920915 (<i>LIPC</i>), rs943080 (<i>VEGFA</i>), rs9542236 (<i>B3GALTL</i>) and rs13081855 (<i>COL8A1/FILIP1L</i>), were genotyped in this cohort. 31819893

2019
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE Prevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed. 29453225

2018
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE This meta-analysis showed that SKIV2L rs429608 was statistically associated with AMD and it might exert a protective effect on AMD. 27484132

2017
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE Rs12153855C and rs9391734A alleles could further increase the susceptibility to AMD in subjects with rs800292, rs11200638 and rs429608 risk alleles. 26861912

2016
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE Genotype distribution of rs1061170 (CFH), rs429608 (SKIV2L), rs2679798 (MYRIP) and both rs11549465 and rs11549467 (HIF1A) in AMD cases and healthy controls; association between genotypes and AMD subtypes. 24995509

2015
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE After adjusting for age, gender, ARMS2 A69S, and CFHI62V, the A allele of rs429608 was significantly protective against neovascular A</span>MD (odds ratio [OR] 0.24, 95% confidence interval [CI] 0.122-0.484, p < 0.001), PCV (OR 0.43, 95% CI 0.262-0.704, p = 0.001), RAP (OR 0.09, 95% CI 0.014-0.581, p = 0.011). 24865191

2014
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
G 0.870 GeneticVariation GWASCAT Seven new loci associated with age-related macular degeneration. 23455636

2013
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation BEFREE The SKIV2L SNPs rs429608 and rs453821 were significantly associated with neovascular AMD (P = 7.39 × 10(-5); odds ratio [OR], 0.22; 95% confidence interval [CI], 0.10-0.50; and P = 0.001; OR, 0.38; 95% CI, 0.21-0.70, respectively), whereas borderline associations were detected for C2 rs547154 (P = 0.002) and RDBP rs760070 (P = 0.003). 23260260

2013
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation GWASDB Seven new loci associated with age-related macular degeneration. 23455636

2013
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation GWASDB Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3. 22694956

2012
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population. 21909106

2011
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation GWASDB Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
0.870 GeneticVariation GWASCAT Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. 20861866

2010
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
G 0.870 GeneticVariation GWASDB Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010
dbSNP: rs429608
rs429608
CYP21A2 ; SKIV2L
G 0.870 GeneticVariation GWASCAT Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. 20385819

2010