rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The study showed that LIPC rs493258 gene and haplotype containing the two minor alleles T-T in rs10468017-rs493258 may decrease AMD development.
|
30399423 |
2019 |
rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates that the T allele in the LIPC rs493258 polymorphism was significantly associated with the risk of any and late AMD.
|
27763569 |
2016 |
rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
The LIPC promoter variants rs493258 and rs10468017 were associated with advanced AMD in two independent Caucasian populations, confirming that LIPC polymorphisms may be a genetic risk factor for AMD in the Caucasian population.
|
23348725 |
2013 |
rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
After multivariate adjustment, the TT genotype of the LIPC rs493258 variant was significantly associated with a reduced risk for early and late AMD (OR=0.64, 95%CI: 0.41-0.99; p=0.049 and OR=0.26, 95%CI: 0.08-0.85; p=0.03, respectively), and with higher plasma zeaxanthin concentrations (p=0.03), while plasma lipids were not significantly different according to this SNP.
|
24223199 |
2013 |
rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
After adjustment for demographic, behavioral, and other genetic factors, a protective effect was detected among TT carriers compared with non-carriers for the HDL pathway gene, LIPC rs493258, for intermediate and late AMD (OR [95% confidence interval]: 0.3 [0.2-0.7], P = .003).
|
21906714 |
2011 |
rs493258
|
|
C |
0.860 |
GeneticVariation |
GWASDB |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
rs493258
|
|
C |
0.860 |
GeneticVariation |
GWASCAT |
Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258).
|
20385826 |
2010 |
rs493258
|
|
C |
0.860 |
GeneticVariation |
GWASDB |
Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258).
|
20385826 |
2010 |
rs493258
|
|
|
0.860 |
GeneticVariation |
BEFREE |
Our discovery data implicated the association between AMD and a variant in the hepatic lipase gene (LIPC) in the high-density lipoprotein cholesterol (HDL) pathway (discovery P = 4.53e-05 for rs493258).
|
20385826 |
2010 |