Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE A significant association between patients with parkinsonism exposed to pesticides and C3435T polymorphism of the MDR1 gene was found. 12724617

2003
dbSNP: rs1045642
rs1045642
ABCB1
0.020 GeneticVariation BEFREE G2677T/A and C3435T genotypes were not associated to psychopathological symptoms, efficacy of treatment and risk for parkinsonism. 20060871

2010
dbSNP: rs2032582
rs2032582
ABCB1
0.010 GeneticVariation BEFREE G2677T/A and C3435T genotypes were not associated to psychopathological symptoms, efficacy of treatment and risk for parkinsonism. 20060871

2010
dbSNP: rs12817488
rs12817488
CCDC62
0.010 GeneticVariation BEFREE Parkinson disease risk alleles in the MAPT (rs2942168; P = .0006) and CCDC62 (rs12817488; P = .004) loci were associated with global parkinsonism, and these associations remained after exclusion of patients with a PD diagnosis. 24514572

2014
dbSNP: rs781442277
rs781442277
CENPO ; PTRHD1 ; LOC105369164
0.010 GeneticVariation BEFREE Given the role of 2p23 locus in patients with intellectual disability and the previously reported PTRHD1 mutation (c.155G>A) in patients with parkinsonism and cognitive dysfunction, we concluded that the PTRHD1 mutation identified in this study is likely to be responsible for the phenotypic features of the family under consideration. 27753167

2017
dbSNP: rs1224426272
rs1224426272
CIT
0.010 GeneticVariation BEFREE Serotonergic pathology and disease burden in the premotor and motor phase of A53T α-synuclein parkinsonism: a cross-sectional study. 31229470

2019
dbSNP: rs1057518882
rs1057518882
CYTB ; ND5 ; ND6
C 0.700 GeneticVariation CLINVAR

dbSNP: rs886039227
rs886039227
DCTN1
0.020 GeneticVariation BEFREE A novel heterozygous mutation, DCTN1 c.156T>G, encoding p.Phe52Leu, segregates with parkinsonism in a Japanese family. 24676999

2014
dbSNP: rs886039227
rs886039227
DCTN1
0.020 GeneticVariation BEFREE A novel F52L DCTN1 mutation case of Perry syndrome is characterized by late-onset parkinsonism and frontotemporal atrophy. 29499916

2018
dbSNP: rs387907571
rs387907571
DNAJC13
0.020 GeneticVariation BEFREE Although the contribution of rare genetic variation in DNAJC13 to parkinsonisms remains to be further elucidated, this study suggests that, in addition to p.N855S, other rare variants might affect disease susceptibility. 25393719

2015
dbSNP: rs387907571
rs387907571
DNAJC13
0.020 GeneticVariation BEFREE Clinical, positron emission tomography, and pathological studies of DNAJC13 p.N855S Parkinsonism. 25186792

2014
dbSNP: rs2421947
rs2421947
DNM3 ; DNM3-IT1
0.010 GeneticVariation BEFREE We found that DNM3 rs2421947 was a haplotype tag for which the median onset of LRRK2 parkinsonism in GG carriers was 12·5 years younger than that of CC carriers (Arab-Berber cohort, hazard ratio [HR] 1·89, 95% CI 1·20-2·98). 27692902

2016
dbSNP: rs112176450
rs112176450
EIF4G1
0.010 GeneticVariation BEFREE Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. 21907011

2011
dbSNP: rs113388242
rs113388242
EIF4G1
0.010 GeneticVariation BEFREE Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. 21907011

2011
dbSNP: rs774457232
rs774457232
EIF4G1
0.010 GeneticVariation BEFREE Subsequent sequence and genotype analysis identified EIF4G1 c.1505C>T (p.Ala502Val), c.2056G>T (p.Gly686Cys), c.3490A>C (p.Ser1164Arg), c.3589C>T (p.Arg1197Trp) and c.3614G>A (p.Arg1205His) substitutions in affected subjects with familial parkinsonism and idiopathic Lewy body disease but not in control subjects. 21907011

2011
dbSNP: rs121918304
rs121918304
FBXO7
0.010 GeneticVariation BEFREE FBXO7-R498X mutation: phenotypic variability from chorea to early onset parkinsonism within a family. 25169713

2014
dbSNP: rs41311141
rs41311141
FBXO7
0.010 GeneticVariation BEFREE After filtering against common variants (minor allele frequency (MAF) < 0.01), 2 noncoding and 1 synonymous rare mutation potentially associable with parkinsonism were identified: GIGYF2-GRB10 Interacting GYF Protein 2, PARK11 (c.*2030G > A, rs115669549); VPS35 gene-vacuolar protein sorting 35, PARK17 (c.102 + 33G > A, rs192115886); and FBXO7-F-box only protein 7 gene, PARK15 (c.540A > G, rs41311141). 27861377

2016
dbSNP: rs762999184
rs762999184
FBXO7
0.010 GeneticVariation BEFREE Analysis of the non-synonymous SNVs that were not shared between the two family members revealed non-synonymous SNVs related to parkinsonism including a novel heterozygous mutation (p.T44N) in FBX07 (PARK15) only in the proband, and non-synonymous SNVs related to neurodegeneration with brain iron accumulation in the affected brother. 25634434

2015
dbSNP: rs104894685
rs104894685
FTL
0.010 GeneticVariation BEFREE The authors identified a missense mutation in the FTL gene (474G>A; A96T) in a 19-year-old man with parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit, and episodic psychosis. 16116125

2005
dbSNP: rs758414077
rs758414077
FTL
0.010 GeneticVariation BEFREE The authors identified a missense mutation in the FTL gene (474G>A; A96T) in a 19-year-old man with parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit, and episodic psychosis. 16116125

2005
dbSNP: rs421016
rs421016
GBA
0.730 GeneticVariation BEFREE α-Synuclein accumulation and GBA deficiency due to L444P GBA mutation contributes to MPTP-induced parkinsonism. 29310663

2018
dbSNP: rs421016
rs421016
GBA
G 0.730 SusceptibilityMutation CLINVAR

dbSNP: rs421016
rs421016
GBA
0.730 GeneticVariation BEFREE Our findings in a representative series of index cases from families with ADPD emphasize the important contribution of LRRK2 G2019S and GBA (L444P and N370S) mutations to parkinsonism in Brazilian families. 27777137

2016
dbSNP: rs421016
rs421016
GBA
0.730 GeneticVariation BEFREE Six GD3 patients, all homoallelic for L444P GBA1 mutations, have lived beyond 40years of age; and none has developed Parkinsonism. 27789132

2018
dbSNP: rs2230288
rs2230288
GBA
T 0.700 SusceptibilityMutation CLINVAR