Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs421016
rs421016
GBA
G 0.730 SusceptibilityMutation CLINVAR

dbSNP: rs1057518882
rs1057518882
CYTB ; ND5 ; ND6
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1555507479
rs1555507479
A 0.700 GeneticVariation CLINVAR

dbSNP: rs2230288
rs2230288
GBA
T 0.700 SusceptibilityMutation CLINVAR

dbSNP: rs756677845
rs756677845
C 0.700 CausalMutation CLINVAR

dbSNP: rs113994097
rs113994097
0.010 GeneticVariation BEFREE Parkinsonism is one of the phenotypic features associated also with the W748S mutation. 18321754

2008

dbSNP: rs761807915
rs761807915
0.010 GeneticVariation BEFREE Parkinsonism with dopa-sensitivity and a correlating DaTSCAN turned out to be due to a D202N mutation which is associated with the Gerstmann-Sträussler-Scheinker (GSS) disease. 23436635

2013

dbSNP: rs2032582
rs2032582
0.010 GeneticVariation BEFREE G2677T/A and C3435T genotypes were not associated to psychopathological symptoms, efficacy of treatment and risk for parkinsonism. 20060871

2010

dbSNP: rs63750424
rs63750424
0.030 GeneticVariation BEFREE R406W homozygotes had an earlier age at onset and a higher frequency of behavioral symptoms and Parkinsonism than heterozygotes. 29370822

2018

dbSNP: rs34637584
rs34637584
0.100 GeneticVariation BEFREE G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice. 31813996

2020

dbSNP: rs121917763
rs121917763
TH
0.030 GeneticVariation BEFREE Leu205Pro polymorphism is a rare mutation that is reported to cause Parkinsonism in infancy for individuals who are homozygous for the mutated type. 9613851

1998

dbSNP: rs63750756
rs63750756
0.100 GeneticVariation BEFREE A mutation in exon 10 of the tau gene, N279K, causes a particular kindred of FTDP-17, which is predominant for parkinsonism. 22169201

2012

dbSNP: rs886039227
rs886039227
0.020 GeneticVariation BEFREE A novel F52L DCTN1 mutation case of Perry syndrome is characterized by late-onset parkinsonism and frontotemporal atrophy. 29499916

2018

dbSNP: rs886039227
rs886039227
0.020 GeneticVariation BEFREE A novel heterozygous mutation, DCTN1 c.156T>G, encoding p.Phe52Leu, segregates with parkinsonism in a Japanese family. 24676999

2014

dbSNP: rs63750444
rs63750444
0.010 GeneticVariation BEFREE A novel mutation (G217D) in the Presenilin 1 gene ( PSEN1) in a Japanese family: presenile dementia and parkinsonism are associated with cotton wool plaques in the cortex and striatum. 12111359

2002

dbSNP: rs63750577
rs63750577
0.010 GeneticVariation BEFREE A review of the available case reports indicates some phenotypic variability associated with the S170F mutation including different constellations of symptoms such as parkinsonism and delusions. 29466804

2018

dbSNP: rs34637584
rs34637584
0.100 GeneticVariation BEFREE A series of 106 patients with isolated or familial Parkinsonism underwent clinical evaluation and genetic testing for the LRRK2 G2019S mutation which was identified in 34/106 patients (32%). 20933457

2010

dbSNP: rs1045642
rs1045642
0.020 GeneticVariation BEFREE A significant association between patients with parkinsonism exposed to pesticides and C3435T polymorphism of the MDR1 gene was found. 12724617

2003

dbSNP: rs34995376
rs34995376
0.010 GeneticVariation BEFREE A third putatively pathogenic variant (R1441H) has been identified in four probands of diverse ethnicity with parkinsonism. 18952485

2009

dbSNP: rs41311141
rs41311141
0.010 GeneticVariation BEFREE After filtering against common variants (minor allele frequency (MAF) < 0.01), 2 noncoding and 1 synonymous rare mutation potentially associable with parkinsonism were identified: GIGYF2-GRB10 Interacting GYF Protein 2, PARK11 (c.*2030G > A, rs115669549); VPS35 gene-vacuolar protein sorting 35, PARK17 (c.102 + 33G > A, rs192115886); and FBXO7-F-box only protein 7 gene, PARK15 (c.540A > G, rs41311141). 27861377

2016

dbSNP: rs63751273
rs63751273
0.030 GeneticVariation BEFREE Agraphia in patients with frontotemporal dementia and parkinsonism linked to chromosome 17 with P301L MAPT mutation: dysexecutive, aphasic, apraxic or spatial phenomenon? 23121543

2014

dbSNP: rs34637584
rs34637584
0.100 GeneticVariation BEFREE All patients carrying the LRRK2 G2019S exhibited typical levodopa-responsive parkinsonism, and severe levodopa-induced dyskinesia was observed in the patient carrying the LRRK2 and parkin mutations. 17388990

2007

dbSNP: rs104893877
rs104893877
0.070 GeneticVariation BEFREE Although cognitive decline has been recognized as a feature of the full-blown clinical picture of p.A53T related parkinsonism, a predominant frontotemporal dementia-like phenotype at presentation has not been previously described. 28012952

2017

dbSNP: rs767543900
rs767543900
0.010 GeneticVariation BEFREE Although cognitive decline has been recognized as a feature of the full-blown clinical picture of p.A53T related parkinsonism, a predominant frontotemporal dementia-like phenotype at presentation has not been previously described. 28012952

2017

dbSNP: rs34637584
rs34637584
0.100 GeneticVariation BEFREE Although effective deep brain stimulation of the subthalamic nucleus (STN-DBS) is reported in G2019S leucine-rich repeat kinase 2 (LRRK2) parkinsonism, response to surgery in other LRRK2 mutations has not been previously reported. 23938256

2012