rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Although an amplification refractory mutation system (ARMS) was shown to be slightly superior in terms of sensitivity, our real-time PCR method provides the potential for quantification of the JAK2 V617F mutation, having potential future applications in the monitoring of minimal residual disease or predicting outcome of disease severity.
|
17251334 |
2007 |
rs1057519743
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As controversy exists regarding the prognostic significance of genomic rearrangements of CRLF2 in pediatric B-precursor acute lymphoblastic leukemia (ALL) classified as standard/intermediate-risk (SR) or high-risk (HR), we assessed the prognostic significance of CRLF2 mRNA expression, CRLF2 genomic lesions (IGH@-CRLF2, P2RY8-CRLF2, CRLF2 F232C), deletion/mutation in genes frequently associated with high CRLF2 expression (IKZF1, JAK, IL7R), and minimal residual disease (MRD) in 1061 pediatric ALL patients (499 HR and 562 SR) on COG Trials P9905/P9906.
|
22368272 |
2012 |
rs9400241
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for rs9400241, the effects were more predominant in children < 10 years, and in patients with pre B ALL, positive MRD, anemia, or hepatomegaly.
|
31691337 |
2020 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM0902) study.
|
23860450 |
2013 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
For JAK2 V617F, the most frequent mutation in myeloproliferative neoplasms, accurate determination of mutational loads is of interest at diagnosis, for phenotypic and prognostic purposes, and during follow-up for minimal residual disease assessment.
|
26596525 |
2016 |
rs17069665
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Further analyses were performed to explore associations of rs17069665 and rs9400241 with ALL susceptibility in terms of age, gender, immunophenotype, minimal residual disease (MRD), and other clinical characteristics.
|
31691337 |
2020 |
rs147001633
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In addition to WT1 overexpression, other MRD positive markers were: NPM1 (Type A, B, K), DNMT3A (R882H), MLL-PTD, IDH1 (R132H) and KRAS (G12S).
|
30457973 |
2019 |
rs121913500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to WT1 overexpression, other MRD positive markers were: NPM1 (Type A, B, K), DNMT3A (R882H), MLL-PTD, IDH1 (R132H) and KRAS (G12S).
|
30457973 |
2019 |
rs104894229
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to WT1 overexpression, other MRD positive markers were: NPM1 (Type A, B, K), DNMT3A (R882H), MLL-PTD, IDH1 (R132H) and KRAS (G12S).
|
30457973 |
2019 |
rs121913530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to WT1 overexpression, other MRD positive markers were: NPM1 (Type A, B, K), DNMT3A (R882H), MLL-PTD, IDH1 (R132H) and KRAS (G12S).
|
30457973 |
2019 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In conclusion, allogeneic stem cell transplantation after dose-reduced conditioning induces high rates of molecular remission in JAK2-positive patients with myelofibrosis, and quantification of V617F-JAK2 mutation by real-time PCR allows the detection of minimal residual disease to guide adoptive immunotherapy.
|
17018857 |
2007 |
rs4149056
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple Cox regression analyses revealed associations of minimal residual disease (MRD) at day 33 (hazard ratio 3.458; P = 0.002), MRD at day 78 (hazard ratio 6.330; P = 0.001), SLCO1B1 rs4149056 (hazard ratio 12.242; P < 0.001), and SCL19A1 rs2838958 (hazard ratio 2.324; P = 0.019) with EFS.
|
28525903 |
2017 |
rs2838958
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Multiple Cox regression analyses revealed associations of minimal residual disease (MRD) at day 33 (hazard ratio 3.458; P = 0.002), MRD at day 78 (hazard ratio 6.330; P = 0.001), SLCO1B1 rs4149056 (hazard ratio 12.242; P < 0.001), and SCL19A1 rs2838958 (hazard ratio 2.324; P = 0.019) with EFS.
|
28525903 |
2017 |
rs2032582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings indicate that there is an effect of the 2677G>T/A polymorphism on progression-free survival in ovarian cancer patients who are treated with a taxane/carboplatin, which is dependent on the extent of residual disease, with a better prognosis for patients with the 2677T/A allele and minimal residual disease.
|
18765553 |
2008 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
QuanTAS-PCR is a simple, cost-efficient, closed-tube method for JAK2 V617F mutation quantification that can detect very low levels of the mutant allele, thus enabling analysis of minimal residual disease.
|
23617802 |
2013 |
rs1789693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in <i>SLCO2B1</i> associated with significant differences in tissue abiraterone (rs1789693, <i>P</i> = 0.0008; rs12422149, <i>P</i> = 0.03) and higher rates of minimal residual disease (tumor volume < 0.5 cc; rs1789693, 67% vs. 27%, <i>P</i> = 0.009; rs1077858, 46% vs. 0%, <i>P</i> = 0.03).
|
28389510 |
2017 |
rs12422149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in <i>SLCO2B1</i> associated with significant differences in tissue abiraterone (rs1789693, <i>P</i> = 0.0008; rs12422149, <i>P</i> = 0.03) and higher rates of minimal residual disease (tumor volume < 0.5 cc; rs1789693, 67% vs. 27%, <i>P</i> = 0.009; rs1077858, 46% vs. 0%, <i>P</i> = 0.03).
|
28389510 |
2017 |
rs1077858
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs in <i>SLCO2B1</i> associated with significant differences in tissue abiraterone (rs1789693, <i>P</i> = 0.0008; rs12422149, <i>P</i> = 0.03) and higher rates of minimal residual disease (tumor volume < 0.5 cc; rs1789693, 67% vs. 27%, <i>P</i> = 0.009; rs1077858, 46% vs. 0%, <i>P</i> = 0.03).
|
28389510 |
2017 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The assay characteristics and our initial evaluation indicate this method can be used for the detection and quantification of JAK2 V617F, which should be useful for diagnosis of myeloproliferative neoplasms and potentially for monitoring minimal residual disease in future trials of therapies targeted to myeloproliferative neoplasms.
|
19959796 |
2010 |
rs77375493
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The combination of ARMS-PCR and capillary electrophoresis enables quantitative assay of JAK2 V617F mutation, which helps in chronic MPD diagnosis and estimation of minimal residual disease.
|
19215672 |
2009 |
rs201478192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combination of ARMS-PCR and capillary electrophoresis enables quantitative assay of JAK2 V617F mutation, which helps in chronic MPD diagnosis and estimation of minimal residual disease.
|
19215672 |
2009 |
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The thymidine kinase inhibitor vemurafenib, which inhibits the V600E mutant of BRAF, was reported to induce a CR in multiply relapsed and refractory HCL, with nearly complete clearing of MRD.
|
23892906 |
2013 |
rs121913377
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The thymidine kinase inhibitor vemurafenib, which inhibits the V600E mutant of BRAF, was reported to induce a CR in multiply relapsed and refractory HCL, with nearly complete clearing of MRD.
|
23892906 |
2013 |
rs1057520009
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Therefore, it was proposed that the XPO1 E571K variant may serve as a minimal residual disease tool in this setting.
|
28196522 |
2017 |
rs387907272
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These observations suggest that ddPCR can sensitively detect the MYD88 L265P mutation in cell-free DNA and could be used as non-invasive diagnostics, but may not be applicable for monitoring minimal residual diseases in PCNSL.
|
29151258 |
2018 |