rs769642939
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|
|
0.010 |
GeneticVariation |
BEFREE |
Inhibition of ERK activity with the MEK inhibitor PD98059 resulted in increased expression of cadherins, while constitutive activation of ERK through the use of expression of an ERK construct with a D319N sevenmaker mutation resulted in decreased expression of cadherins and enhanced colony formation of HT-1080 fibrosarcoma cells.
|
30689107 |
2019 |
rs889472
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0.010 |
GeneticVariation |
BEFREE |
A recent meta-analysis of genome-wide association studies has newly identified the relationship between serum uric acid (SUA) levels and rs889472, a single nucleotide polymorphism of musculoaponeurotic fibrosarcoma oncogene (MAF/c-MAF).
|
29080939 |
2018 |
rs121913499
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|
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0.010 |
GeneticVariation |
BEFREE |
Here, using a genetically engineered inducible system, we report that selective suppression of endogenous mutant IDH1 expression in HT1080, a fibrosarcoma cell line with a native IDH1(R132C) heterozygous mutation, significantly inhibits cell proliferation and decreases clonogenic potential.
|
22885298 |
2012 |
rs104894229
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|
|
0.010 |
GeneticVariation |
BEFREE |
To gain an understanding of the relationship between constitutional HRAS mutations and malignancy, HRAS was sequenced in an advanced biphasic rhabdomyosarcoma/fibrosarcoma from an individual with a 34G --> A mutation.
|
16372351 |
2006 |
rs1284410244
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|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
rs765431049
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|
|
0.010 |
GeneticVariation |
BEFREE |
To directly assess its role in tumor growth and metastasis in vivo, we stably transfected HT-1080 fibrosarcoma cells expressing either fully active wild-type human TFPI-2 (WT) or inactive R24Q TFPI-2 (QT) and examined their ability to form tumors and metastasize in athymic mice in comparison to mock-transfected cells (MT).
|
14525759 |
2004 |
rs113488022
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Similar targeting of BRAF(V599E) or wild-type BRAF in human fibrosarcoma cells that lack the BRAF(V599E) mutation does not recapitulate these effects.
|
14500344 |
2003 |
rs121913377
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|
|
0.010 |
GeneticVariation |
BEFREE |
Similar targeting of BRAF(V599E) or wild-type BRAF in human fibrosarcoma cells that lack the BRAF(V599E) mutation does not recapitulate these effects.
|
14500344 |
2003 |
rs17576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
With the exception of one amino-acid substitution at position 280 (Arg-->Gln), the deduced amino-acid sequences of neutrophil gelatinase are identical to the amino-acid sequences of the enzyme isolated from fibrosarcoma cells.
|
8305481 |
1994 |