|
rs1801394
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs1801394
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Moreover, we found that MTRR A66G (rs1801394) variant genotypes was associated with increased risk of meni</span>ngioma and glioma (G vs. A: OR=1.11, P=0.020; GG vs. AA+AG: OR=1.17, P=0.043; GG vs. AA: OR=1.22, P=0.023).
|
28915669 |
2017 |
|
rs1801394
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Our study suggested that MTHFR C677T and MTRR A66G variants may affect the risk of adult meningioma in Chinese Han population.
|
23959833 |
2013 |
|
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The polymorphisms rs4968451T>G in BRIP1 were significantly associated with the risk of meningioma (TT vs. TG vs. GG additive, P = 0.005; TT+TG vs. GG dominant, P = 0.015; TT/GT+GG recessive, P = 0.034).
|
29581016 |
2018 |
|
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
|
rs1801131
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Our updated meta-analysis provided statistical evidence for the role of <i>MLLT10</i> rs12770228, <i>MTRR</i> rs1801394, and <i>MTHFR</i> rs1801131 in increased susceptibility to meningioma.
|
28405167 |
2017 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The CASP8 D302H polymorphism genotypic frequencies were not statistically significantly different between meningioma cases and controls, with frequencies of GG, GC and CC genotypes of 71.2%, 19,2% and 9.6%; and 57.9%, 36.8% and 5.3%, respectively.
|
26359420 |
2016 |
|
rs12770228
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The variant 'A' allele in MLLT10 rs12770228 was associated with an increased risk of meningioma (per allele odds ratio: 1.25; 95% confidence interval: 1.02, 1.53; P=0.031).
|
24755950 |
2015 |
|
rs1045485
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n=631 and 637, respectively).
|
18823701 |
2009 |
|
rs4968451
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We have identified a novel association between rs4968451 and meningioma risk.
|
18270339 |
2008 |
|
rs10936599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs150766139
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The carrier of c.268C>T (p.Q90*) and 550-1G>A was diagnosed with CRC and meningioma at ages 37 and 45 respectively, being reclassified as attenuated adenomatous polyposis after the cumulative detection of 26 adenomas.
|
31227763 |
2019 |
|
rs2235544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The C-allele of the DI01 SNP rs2235544 was related to increased circulating free T3/ free T4 ratio in glioma and meningioma patients, indicating greater T4 to T3 conversion.
|
31452060 |
2019 |
|
rs2736100
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs3731249
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We report an undescribed p.(Ala148Thr) CDKN2A mutation in meningioma that was only present in relapsing tumors.
|
31729637 |
2019 |
|
rs603965
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Moreover, in stratified analyses by type of disease, we noticed that the rs603965 polymorphism was significantly associated with the susceptibility to glioma, but such positive results were not detected in pituitary adenoma or meningioma.
|
30972946 |
2019 |
|
rs9420907
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39).
|
30796745 |
2019 |
|
rs2686876
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a new susceptibility locus for meningioma at 11p15.5 (rs2686876, odds ratio = 1.44, P = 9.86 × 10-9).
|
29762745 |
2018 |
|
rs397507444
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults.
|
28915669 |
2017 |
|
rs1243180
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We genotyped two tightly linked single-nucleotide polymorphisms (SNPs) at MLLT10 associated with meningioma (rs12770228) or ovarian cancer (rs1243180), and tested for associations among 295 meningioma cases, 606 glioma cases and 646 noncancer controls, all of European descent.
|
24755950 |
2015 |
|
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The current meta-analysis firstly provides evidence that the MTHFR C677T polymorphism may modify the risk for brain tumors, particularly meningioma.
|
23846816 |
2013 |
|
rs267606541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genetic analysis in a patient presenting with meningioma and familial isolated pituitary adenoma (FIPA) reveals selective involvement of the R81X mutation of the AIP gene in the pathogenesis of the pituitary tumor.
|
22527616 |
2012 |
|
rs11012732
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)).
|
21804547 |
2011 |
|
rs1035938
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed significantly increased risk of meningioma with the T variant of GLTSCR1 rs1035938 (OR(CT/TT) = 3.5; 95% confidence interval: 1.8-6.9; P(trend) .0006), which persisted after controlling for multiple comparisons (P = .019).
|
20150366 |
2010 |