|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for gastric cancer (P = 8.40 x 10(-9); per-allele odds ratio (OR) = 1.31) and ESCC (P = 3.85 x 10(-9); OR = 1.34).
|
20729852 |
2010 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP, rs2274223) in PLCE1 has been identified as a novel susceptibility locus in genome-wide association studies (GWAS) of esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinoma (GCA) that share similar risk factors with SCCHN.
|
21689432 |
2011 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Consistent with the previous study, loci at rs2074356 and rs2274223 could increase the risk of ESCC, furthermore, there were significant interactions between HPV sero-status and the susceptibility loci on the risk of ESCC.
|
25008389 |
2014 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Especially, the risk effects of rs2274223 were more evident in poor differentiation and advanced clinical stages of Kazakh ESCC.
|
23981775 |
2013 |
|
rs71031566
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we report the functional characterization of a four-nucleotide insertion/deletion variation (rs71031566 C----/CATTT) in PLCE1 that was associated with risk of developing ESCC.
|
29106514 |
2018 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In additional, five variants on five genes were rated as strong cumulative epidemiological evidence for a nominally significant association with EC and ESCC risk, including CYP1A1 rs1048943, EGF rs444903, HOTAIR rs920778, MMP2 rs243865, and PLCE1 rs2274223, 10 variants were rated as moderate, and 18 variants were rated as weak.
|
30793520 |
2019 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In conclusion, PLCE1 rs2274223 polymorphism may be used as a potential biomarker for DTC susceptibility particularly for ESCC and GCA in the Chinese population.
|
24874112 |
2014 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In contrast to the modulation of the risk of ESCC in Asians, it is unlikely that the PLCE1 rs2274223 and RFT2 13042395 SNPs play a role in EAC or ESCC susceptibility in Dutch Caucasians.
|
23222411 |
2013 |
|
rs17417407
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In the present study, we validated this finding and also explored the risk of ESCC associated with other two unreported potentially functional SNPs (rs17417407 G>T and rs2274224 C>G) of PLCE1 in a population-based case-control study to investigate the association between these three potentially functional SNPs in PLCE1 and susceptibility to ESCC.
|
23688607 |
2013 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
In this meta-analysis, the PLCE1 rs2274223 polymorphism was confirmed to have a statistically significant association with an increasing risk of ESCC and gastric cancer.
|
23826241 |
2013 |
|
rs2274223
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
|
25129146 |
2014 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Meta-analysis found significant associations between rs2274223 and ESCC under all analyzed genetic models.
|
30666517 |
2019 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
Our meta-analysis results indicated that PLCE1 rs2274223 G allele significantly contributed to the risk of ESCC and GCA, especially in Chinese population.
|
23874915 |
2013 |
|
rs7922612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study for the first time suggests that GWAS originated PLCE1 variants do not have independent role in susceptibility of ESCC in northern Indian population; however, a novel haplo-tagging SNP rs7922612 may modify survival outcome of ESCC patients.
|
25139097 |
2014 |
|
rs11599672
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Overall, rs11599672 SNP had no influence on ESCC susceptibility.
|
23079034 |
2012 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
PLCE1 SNP rs2274223 A>G change may reduce gene expression, and the variant G genotypes might contribute to risk of ESCC.
|
22203178 |
2012 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
SNP rs2274223 was independently associated with increased risk of ESCC (adjusted odds ratio [OR], 2.80; 95% confidence interval [95% CI], 1.45-5.39 for GG vs. AA), and SNP rs2274224 was found to be associated with decreased risk of ESCC (adjusted OR, 0.65; 95% CI, 0.46-0.91 for CG vs. CC).
|
23688607 |
2013 |
|
rs2274224
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2274223 was independently associated with increased risk of ESCC (adjusted odds ratio [OR], 2.80; 95% confidence interval [95% CI], 1.45-5.39 for GG vs. AA), and SNP rs2274224 was found to be associated with decreased risk of ESCC (adjusted OR, 0.65; 95% CI, 0.46-0.91 for CG vs. CC).
|
23688607 |
2013 |
|
rs11187870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP rs2274223 was independently associated with risk of ESCC (adjusted odds ratio [OR], 1.49; 95% confidence interval [95% CI], 1.03-2.17 for GG vs AA), and SNP rs11187870 was also found to be associated with risk of ESCC assuming a dominant model (adjusted OR, 1.20; 95% CI, 1.00-1.44 for CG/CC vs GG).
|
22203178 |
2012 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
So, we aimed to replicate association of two previously reported non-synonymous polymorphisms (rs2274223A>G and rs3765524C>T) from haplotype block 10 and evaluated a novel variant (rs7922612C>T) from haplotype block 2 of PLCE1 with susceptibility and prognosis of ESCC in northern Indian population.
|
25139097 |
2014 |
|
rs3765524
|
|
|
0.020 |
GeneticVariation |
BEFREE |
So, we aimed to replicate association of two previously reported non-synonymous polymorphisms (rs2274223A>G and rs3765524C>T) from haplotype block 10 and evaluated a novel variant (rs7922612C>T) from haplotype block 2 of PLCE1 with susceptibility and prognosis of ESCC in northern Indian population.
|
25139097 |
2014 |
|
rs7922612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
So, we aimed to replicate association of two previously reported non-synonymous polymorphisms (rs2274223A>G and rs3765524C>T) from haplotype block 10 and evaluated a novel variant (rs7922612C>T) from haplotype block 2 of PLCE1 with susceptibility and prognosis of ESCC in northern Indian population.
|
25139097 |
2014 |
|
rs17109671
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results showed that CC genotype of both PLCE1 rs17109671 and EGFR rs2072454 was associated with ESCC prognosis.
|
31209807 |
2019 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
These results highlighted the role of a genetic factor in ESCC and suggested that the PLCε1 rs2274223 SNP might be an effective genetic marker to assess the risk of ESCC in individuals with a UGIC family history from a region of high incidence in northern China.
|
23079034 |
2012 |
|
rs2274223
|
|
|
0.800 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrated that PLCE1 rs2274223 A > G polymorphism may be associated with increased susceptibility to cancer, especially for ESCC.
|
25614244 |
2015 |