Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The MTHFR C677T genotype and serum vitamin B<sub>2</sub> or B<sub>12</sub> levels may interact in ways which associated with the EPL and ESCC risks. 31754346

2019

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE A link between MTHFR C677T polymorphisms and oesophageal squamous cell carcinoma and gastric cardia adenocarcinoma has been demonstrated in at risk Chinese populations. 25232254

2014

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T. 23534726

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE MTHFR 677 C>T polymorphism was associated with the risk of ESCC by using chi-square tests (P<0.05). 24393513

2013

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism and folate intake in esophageal squamous cell carcinoma. 23244153

2012

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE We here aimed to evaluate associations of MTHFR C677T and A1298C polymorphisms with ESCC. 22126580

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE However, the TT genotype of MTHFR C677T only increased the risk of ESCC. 21672255

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE No significant relation was observed between aberrant DNA methylation of P16, MGMT and hMLH1 gene, as well as MTHFR C677T genetic polymorphisms and the prognosis of ESCC. 21375764

2011

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Aberrant DNA methylation of P16, MGMT, and hMLH1 genes in combination with MTHFR C677T genetic polymorphism in esophageal squamous cell carcinoma. 18199718

2008

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The association between the MTHFR C677T and SHMT ( 1 ) C1420T polymorphisms and the risk of ESCC and GCA was demonstrated. 17206530

2007

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The prognostic significance of genetic polymorphisms (Methylenetetrahydrofolate Reductase C677T, Methionine Synthase A2756G, Thymidilate Synthase tandem repeat polymorphism) in multimodally treated oesophageal squamous cell carcinoma. 16333305

2006

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE The distribution of the MTHFR C677T genotypes among German ESCC patients (C/C, 39.0%, C/T, 48.1%, T/T, 12.9%) was not significantly different from that among healthy controls (chi(2)=0.531, P=0.767). 15449187

2004

dbSNP: rs1217691063
rs1217691063
0.100 GeneticVariation BEFREE Our results suggest that the MTHFR C677T and MTRR A66G polymorphisms influence the risk of ESCC and GCA in this population. 14652285

2003