|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Previously, we identified that rs1229984 in ADH1B, rs671 in ALDH2, and smoking status were independently associated with the risk of developing metachronous squamous cell carcinoma (SCC) after endoscopic resection (ER) for esophageal SCC (ESCC).
|
30173282 |
2019 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Moreover, we found cumulative effects of these two genetic factors (rs1229984 GG and rs671 GA) and one environmental factor (tobacco smoking) which appear to increase metachrous SCCs after ESD of ESCC risk approximately nearly 12-fold.
|
27038040 |
2016 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found that subjects carrying the rs1229984 GG genotype had significantly increased risk of ESCC (adjusted OR, 2.81; 95% CI, 2.18-3.62; p=1.05 × 10-15) compared with the AA genotype.
|
24093763 |
2014 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Thus, our findings indicate that rs1494961 at 4q21, rs1229984 and rs1789924 at 4q23, and rs671 at 12q24 may be used as genetic biomarkers for ESCC susceptibility in Chinese population.
|
23430454 |
2013 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption.
|
21157980 |
2010 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
A dataset composed of 4,220 cases and 8,946 controls from twelve studies of Asian populations was analyzed for ADH1B Arg47His association with ESCC and its interactions with alcohol drinking and ALDH2 Glu504Lys.
|
21048924 |
2010 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
By integrating both genetic and environmental risk factors, it was shown that the combination of rs1229984 and rs671 risk alleles with smoking and alcohol consumption was associated with OSCC.
|
20833657 |
2010 |
|
rs1229984
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We identified the significant associations of ESCC with 4q21-23 and 12q24 regions, which include nonsynonymous single nucleotide polymorphisms (SNP) in ADH1B (rs1229984, P = 6.76 x 10(-35)) and ALDH2 (rs671, P = 3.68 x 10(-68)) that were previously shown to be associated with ESCC susceptibility.
|
19698717 |
2009 |