Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs25487
rs25487
0.020 GeneticVariation BEFREE Eighty-eight patients with laryngeal SCC and 178 randomly selected healthy blood donors from the same Caucasian population (Porto, Northern Portugal) were analysed for CYP1A1 (MspI and NcoI) and XRCC1 (Arg194Trp and Arg399Gln) polymorphisms, using PCR-RFLP techniques. 14639127

2003

dbSNP: rs1799782
rs1799782
0.010 GeneticVariation BEFREE Eighty-eight patients with laryngeal SCC and 178 randomly selected healthy blood donors from the same Caucasian population (Porto, Northern Portugal) were analysed for CYP1A1 (MspI and NcoI) and XRCC1 (Arg194Trp and Arg399Gln) polymorphisms, using PCR-RFLP techniques. 14639127

2003

dbSNP: rs770140945
rs770140945
0.010 GeneticVariation BEFREE Eighty-eight patients with laryngeal SCC and 178 randomly selected healthy blood donors from the same Caucasian population (Porto, Northern Portugal) were analysed for CYP1A1 (MspI and NcoI) and XRCC1 (Arg194Trp and Arg399Gln) polymorphisms, using PCR-RFLP techniques. 14639127

2003

dbSNP: rs1229984
rs1229984
0.010 GeneticVariation BEFREE The aim of this study was to determine the distribution of alcohol dehydrogenase-1B polymorphism (Arg48His; rs1229984) in our region and analyze its association with the risk of oral and laryngeal squamous cell carcinoma. 21378355

2011

dbSNP: rs25487
rs25487
0.020 GeneticVariation BEFREE The results from this present meta-analysis suggest that XRCC1 Arg399Gln variants may contribute to HNSCC risk among Caucasians and to the risk of larynx squamous cell carcinoma. 24205020

2013

dbSNP: rs10492336
rs10492336
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs174549
rs174549
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs2857595
rs2857595
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs310518
rs310518
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs40129
rs40129
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs9445023
rs9445023
0.700 GeneticVariation GWASCAT Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. 25194280

2014

dbSNP: rs1057519847
rs1057519847
0.010 GeneticVariation BEFREE Two LSCC specimens were positive for EGFR exon 21 mutation (1.52%).The mutation was p.L858R in exon 21. 24646139

2014

dbSNP: rs1057519848
rs1057519848
0.010 GeneticVariation BEFREE Two LSCC specimens were positive for EGFR exon 21 mutation (1.52%).The mutation was p.L858R in exon 21. 24646139

2014

dbSNP: rs121434568
rs121434568
0.010 GeneticVariation BEFREE Two LSCC specimens were positive for EGFR exon 21 mutation (1.52%).The mutation was p.L858R in exon 21. 24646139

2014

dbSNP: rs121434569
rs121434569
0.010 GeneticVariation BEFREE Of the 132 LSCC specimens examined, only 1 specimen was found to be positive for EGFR exon 20 mutation (0.76%).The mutation was p.T790M in exon 20. 24646139

2014

dbSNP: rs1043210477
rs1043210477
0.010 GeneticVariation BEFREE We investigated whether the polymorphisms of MnSOD (Ala-9Val, rs4880) and GPx1 (Pro198Leu, rs1050450) are associated with LSCC and also evaluated possible interactions between these polymorphisms and various lifestyle factors or pathological features of patients. 27188866

2016

dbSNP: rs1050450
rs1050450
0.010 GeneticVariation BEFREE We investigated whether the polymorphisms of MnSOD (Ala-9Val, rs4880) and GPx1 (Pro198Leu, rs1050450) are associated with LSCC and also evaluated possible interactions between these polymorphisms and various lifestyle factors or pathological features of patients. 27188866

2016

dbSNP: rs11903757
rs11903757
0.010 GeneticVariation BEFREE We found that the single nucleotide polymorphisms (SNPs), rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in LSCC patients. 27793000

2016

dbSNP: rs4880
rs4880
0.010 GeneticVariation BEFREE We investigated whether the polymorphisms of MnSOD (Ala-9Val, rs4880) and GPx1 (Pro198Leu, rs1050450) are associated with LSCC and also evaluated possible interactions between these polymorphisms and various lifestyle factors or pathological features of patients. 27188866

2016

dbSNP: rs966423
rs966423
0.010 GeneticVariation BEFREE We found that the single nucleotide polymorphisms (SNPs), rs11903757, with closest proximity to NABP1 and SDPR, and rs966423 in DIRC3, were associated with survival in LSCC patients. 27793000

2016

dbSNP: rs11886868
rs11886868
0.010 GeneticVariation BEFREE BCL11A rs11886868 and rs4671393 genotype variations and correspondingly high BCL11A plasma levels are related to LSCC, besides, differences in plasma levels and genotype distribution may be related to lymph node metastasis status and the stage of LSCC. 28225775

2017

dbSNP: rs4671393
rs4671393
0.010 GeneticVariation BEFREE BCL11A rs11886868 and rs4671393 genotype variations and correspondingly high BCL11A plasma levels are related to LSCC, besides, differences in plasma levels and genotype distribution may be related to lymph node metastasis status and the stage of LSCC. 28225775

2017

dbSNP: rs1052133
rs1052133
0.010 GeneticVariation BEFREE Our meta-analysis results indicated that <i>hOGG1</i> Ser326Cys polymorphism may be associated with increased risk of HNSCC, especially in Caucasians, alcohol drinkers and the patients with laryngeal squamous cell carcinoma. 29560133

2018

dbSNP: rs11614913
rs11614913
0.010 GeneticVariation BEFREE These findings underline the importance of the SNP rs11614913 for LSCC development in the Polish population and moreover highlight the different genetic background of the two studied neoplasms of the head and neck region. 29705927

2018

dbSNP: rs4959235
rs4959235
0.010 GeneticVariation BEFREE To understand the association between SNPs in SLC22A23 and LSCC, selected genetic variations (rs4959235, rs6923667, rs9503518) were genotyped. 29703252

2018