|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In a multivariate analysis, presence of villous histology and high-grade dysplasia was associated with KRAS mutations (OR, 3.0; 95% CI, 1.7-5.4 and OR, 3.5; 95% CI 1.9-6.5, respectively), while serrated adenomas and hyperplastic polyps were associated with BRAF V600E mutations (OR, 20.6; 95% CI, 8.2-51.8 and OR, 11.9; 95% CI 4.9-29.0, respectively).
|
26910894 |
2016 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results also provide evidence that--just as BRAF V600E mutations in hyperplastic polyps and benign nevi- a mutated driver gene does not imply malignant behavior per se but may set the basis for malignant transformation.
|
26493284 |
2016 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The BRAF V600E mutation is one of the most frequent molecular abnormalities identified in hyperplastic polyps and sessile serrated adenomas.
|
26030242 |
2015 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We investigated 194 serrated lesions of the colon, comprising 42 sessile serrated adenomas/polyps, 16 traditional serrated adenomas, 136 hyperplastic polyps and 20 tubular/tubulovillous adenomas (conventional adenomas) with the novel BRAF V600E mutation-specific antibody VE1.
|
23887306 |
2014 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
BRAF mutations (V600E) were observed in 45.8% (11 of 24) of HPs, 60.9% (14 of 23) of SSAs, and 63.6% (7 of 11) of SSANs, and were equally found in both SSA and carcinoma/HGD areas of the individual SSANs.
|
21263251 |
2011 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
BRAF V600E mutations were seen in 83% of proximal and 74% of distal hyperplastic polyps.
|
19855373 |
2010 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
BRAF V600E mutation analysis was performed in 148 selected cases; mutations were found in 44/49 (90%) of lesions diagnosed as sessile serrated adenoma, in 10/34 (29%) of hyperplastic polyps of microvesicular type, in 4/11 (36%) of traditional serrated adenomas, in 10/10 (100%) of mixed hyperplastic adenomatous polyps, and in 2/42 (5%) of "conventional" adenomas.
|
19126563 |
2009 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Both the HP and TSA exhibited the V600E BRAF mutation without MSI or MMR deficiency.
|
17914558 |
2007 |
|
rs113488022
|
|
|
0.090 |
GeneticVariation |
BEFREE |
These findings indicate that adenomas might be less important in the cancer development in the group of families with BRAF-V600E mutations and indirectly support a previous hypothesis that tumors might develop through the hyperplastic polyp-serrated adenoma pathway.
|
17119056 |
2006 |