rs63751273
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Altogether, these results suggest a sex dependent neuroprotective effect of LFPD in P301L-tg mice, suggesting that lifestyle intervention strategies may be clinically relevant for delaying the onset of cognitive impairment and dementia, especially in females.
|
28456717 |
2017 |
rs63751438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we found that LA supplementation effectively inhibited the hyperphosphorylation of Tau at several AD-related sites, accompanied by reduced cognitive decline in P301S Tau transgenic mice.
|
29126071 |
2018 |
rs63751273
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Here, we studied the effects of P301L hTau transduction in the medial EC (MEC) of mice on tau phosphorylation and accumulation, and cognitive deficit.
|
28634382 |
2017 |
rs63751273
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.
|
29568692 |
2018 |
rs63750424
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results prove that combination of the V337M and R406W mutations of tau accelerates human tau phosphorylation and induces tau pathology as well as cognitive deficits, making this model a suitable tool for basic research on tau as well as in vivo drug testing.
|
22797329 |
2013 |
rs63750756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The behavioral phenotype of N279K mice mimics features of human FTDP-17 and provides a basic model for elucidating mechanisms underlying cognitive deficits in not only FTDP-17, but also diverse tauopathies.
|
16219306 |
2005 |
rs63751273
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Unexpectedly, we found that 4R NM human tau (hTau) exhibited abnormal dynamics in young mice that were lost with the P301L mutation, including elevated protein stability and hyperphosphorylation, which were associated with cognitive impairment in 5-month old rT1 mice.
|
31685653 |
2020 |
rs63750756
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously established a transgenic mouse with human N279K mutant tau as a model for FTDP-17, which showed cognitive dysfunctions caused by the mutant.
|
22169201 |
2012 |