Utilizing the population-based genome-wide study of the Taiwan Biobank containing the data of 2533 healthy aging subjects, we found after adjustments for age, sex, education years, and principal components at a suggestive level of 1 × 10<sup>-5</sup> that minor alleles of <i>leucine rich repeat transmembrane neuronal 4 (LRRTM4)</i> (rs13388459, rs1075716, rs62171995, rs17406146, rs2077823, and rs62170897), <i>proprotein convertase subtilisin/kexin type 5</i> (<i>PCSK5)</i> (rs10521467), and the intergenic variation rs117129097 (the nearby gene: <i>TMEM132C</i>) are risk factors for CI in hypotensive subjects.