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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Low folate intake and genetic variants in folate metabolism, such as the methylenetetrahydrofolate reductase (MTHFR) 677 C>T polymorphism, have been suggested to impact brain function and increase the risk for cognitive decline and late-onset Alzheimer's disease.
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30288696 |
2019 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Both CT genotype and T allele of MTHFR C677T gene polymorphism were found to pose significant decreased risk for CI.
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30245375 |
2018 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
Apolipoprotein E epsilon-4 (APOE ε4) allele, methylenetetrahydrofolate reductase (MTHFR C677T), and methionine synthase (MTR A2756G) were tested their associations with cognitive impairment in people with late-life depression (LLD).
|
27111719 |
2017 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
We designed this study to determine if tHcy is causally related to cognitive impairment in later life by investigating its association with high tHcy and the MTHFR-C677T polymorphism.
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21358708 |
2012 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
|
22739363 |
2012 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
These data suggest that both MTHFR C677T and eNOS G894T variants should be regarded as genetic risk factors for hyperhomocysteinemia in patients with cognitive decline.
|
21607713 |
2011 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
The T allele in a C677T variant in methylenetetrahydrofolate reductase (MTHFR) gene is associated with elevated plasma homocysteine, which is detrimental to vascular integrity and has been linked to cognitive decline.
|
19013496 |
2009 |
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rs1217691063
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|
0.100 |
GeneticVariation |
BEFREE |
Hyperhomocysteinemia, intima-media thickness and C677T MTHFR gene polymorphism: a correlation study in patients with cognitive impairment.
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19342053 |
2009 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Although the intermediate mechanisms for C677T effects remain uncertain, these results suggest that MTHFR-related cognitive impairment and negative symptoms reflect differing neural substrates.
|
17344026 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
Methylenetetrahydrofolate reductase 677C>T and methionine synthase 2756A>G mutations: no impact on survival, cognitive functioning, or cognitive decline in nonagenarians.
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17339646 |
2007 |
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rs1217691063
|
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|
0.100 |
GeneticVariation |
BEFREE |
To elucidate the specific role of the TT genotype of MTHFR in the development of cerebral infarction with and without cognitive impairment, we determined the prevalence of hyperhomocyst(e)inemia and the C677T genotypes of MTHFR in 143 patients with vascular dementia, 122 patients with cerebral infarction, and 217 healthy subjects matched for age and sex.
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10938012 |
2000 |