Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1057518809
rs1057518809
FBN1
C 0.700 GeneticVariation CLINVAR

dbSNP: rs1057518973
rs1057518973
FBN1
G 0.700 GeneticVariation CLINVAR

dbSNP: rs121908029
rs121908029
LDLR
A 0.700 CausalMutation CLINVAR

dbSNP: rs137854466
rs137854466
FBN1
A 0.700 CausalMutation CLINVAR

dbSNP: rs137854467
rs137854467
FBN1
A 0.700 CausalMutation CLINVAR

dbSNP: rs1553507345
rs1553507345
COL3A1
AA 0.700 GeneticVariation CLINVAR

dbSNP: rs727503057
rs727503057
FBN1
A 0.700 CausalMutation CLINVAR

dbSNP: rs10263935
rs10263935
KCTD7
0.010 GeneticVariation BEFREE After adjustment of the confounding factors, such as smoking, sex, and age, the differences remain significant in several models (rs10263935: GG vs AA: OR = 3.13, 95% CI: 1.15-8.33, P = 0.025; GG vs AG: OR = 1.57, 95% CI: 1.01-2.44, P = 0.045; rs6045676: GG vs CC: OR = 3.30, 95% CI: 1.32-8.25, P = 0.011). rs10263935 on chromosome 7 and rs6045676 on chromosome 20 are associated with AD. 25417718

2015
dbSNP: rs1036477
rs1036477
FBN1
0.010 GeneticVariation BEFREE Our study provides evidence for the following: (i) FBN1 SNPs rs2118181, rs1036477, rs10519177, rs4774517, rs755251 may increase susceptibility to aortic dissections and (ii) FBN1 SNPs rs2118181, rs1036477 to the formation of aortic aneurysms. 25583878

2015
dbSNP: rs2118181
rs2118181
FBN1
0.010 GeneticVariation BEFREE Our study provides evidence for the following: (i) FBN1 SNPs rs2118181, rs1036477, rs10519177, rs4774517, rs755251 may increase susceptibility to aortic dissections and (ii) FBN1 SNPs rs2118181, rs1036477 to the formation of aortic aneurysms. 25583878

2015
dbSNP: rs4774517
rs4774517
FBN1
0.010 GeneticVariation BEFREE Our study provides evidence for the following: (i) FBN1 SNPs rs2118181, rs1036477, rs10519177, rs4774517, rs755251 may increase susceptibility to aortic dissections and (ii) FBN1 SNPs rs2118181, rs1036477 to the formation of aortic aneurysms. 25583878

2015
dbSNP: rs6045676
rs6045676
PDYN-AS1
0.010 GeneticVariation BEFREE After adjustment of the confounding factors, such as smoking, sex, and age, the differences remain significant in several models (rs10263935: GG vs AA: OR = 3.13, 95% CI: 1.15-8.33, P = 0.025; GG vs AG: OR = 1.57, 95% CI: 1.01-2.44, P = 0.045; rs6045676: GG vs CC: OR = 3.30, 95% CI: 1.32-8.25, P = 0.011). rs10263935 on chromosome 7 and rs6045676 on chromosome 20 are associated with AD. 25417718

2015
dbSNP: rs755251
rs755251
FBN1
0.010 GeneticVariation BEFREE Our study provides evidence for the following: (i) FBN1 SNPs rs2118181, rs1036477, rs10519177, rs4774517, rs755251 may increase susceptibility to aortic dissections and (ii) FBN1 SNPs rs2118181, rs1036477 to the formation of aortic aneurysms. 25583878

2015
dbSNP: rs2274756
rs2274756
MMP9 ; SLC12A5-AS1
0.010 GeneticVariation BEFREE The G allele frequency for the MMP-9 SNP rs2274756 was significantly higher in female TAD patients than in female controls (P=0.0099). 24487965

2014
dbSNP: rs730880099
rs730880099
FBN1
0.010 GeneticVariation BEFREE She had no systemic characteristics of Marfan syndrome, however she exhibited a mutation of FBN1, Arg 545 Cys, which has been found to correlate with ectopia lentis but not with aortic dissection. 23719250

2013
dbSNP: rs2359612
rs2359612
VKORC1
0.010 GeneticVariation BEFREE Recently, the C-allele of polymorphism rs2359612 (VKORC1: c.283+837C>T) in the VKORC1 gene has been reported to represent a major risk factor for coronary heart disease (CHD), stroke, and aortic dissection in Chinese patients. 17549303

2007