rs1406835103
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Recently, we proposed type 1/2 (large/small duct types) classification of ICC based on mucin productivity and immunophenotypes (S100P, N-cadherin, and NCAM).
|
30349952 |
2019 |
rs768617095
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, tissue expression of BAP-1, PBRM-1, S100P, and miR-31 was investigated in ICC and correlated with clinical-pathological features.
|
30377796 |
2019 |
rs121913530
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Molecular studies showed one mucinous iCC with KRAS G12C mutation and no BRAF or IDH1/2 mutations.
|
29698701 |
2018 |
rs183606230
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The combined evaluation of histology of CD and protein expression status of CRP, CDH2, TFF1 and S100P might help subtyping and predicting clinical outcomes of iCCA.
|
28608943 |
2018 |
rs368054556
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MYST3 mutation at Q1388H detected in intrahepatic cholangiocarcinoma is reported for the first time.
|
29559246 |
2018 |
rs754332870
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Molecular studies showed one mucinous iCC with KRAS G12C mutation and no BRAF or IDH1/2 mutations.
|
29698701 |
2018 |
rs121913499
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three cases in iCC (6.5%) and five cases in HCC (10.4%) had IDH1 mutation, all of which were Arg132Cys.
|
28403884 |
2017 |
rs121913500
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistochemistry using monoclonal antibody MsMab-2 is useful to detect IDH1 R132L in intrahepatic cholangiocarcinoma.
|
27595804 |
2016 |
rs2257205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RNF43 reduced expression in ICC, and the reduction of RNF43 messenger RNA expression was significantly correlated with the presence of rs2257205 and RNF43 somatic mutations, confirming that all RNF43 somatic mutations in ICC are inactivating.
|
26980022 |
2016 |
rs1042522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
rs1131691014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
rs1217691063
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
rs878854066
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
rs879253942
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We performed a case-control association study to evaluate the association between common polymorphisms in MTHFR (C677T and A1298C) and the Arg72Pro polymorphism in the p53 gene and the risk for cervical intraepithelial neoplasia (CIN) or invasive cervical cancer (ICC) in Mexican HPV-infected women.
|
24474455 |
2014 |
rs762846821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Tissue-specific activation of Kras(G12D) alone resulted in the development of invasive IHCC with low penetrance and long latency.
|
22266220 |
2012 |
rs758272654
|
|
|
0.010 |
GeneticVariation |
BEFREE |
GNAS1 T393C is a novel independent host factor for disease progression in patients with ICC.
|
17356712 |
2007 |
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
This study suggests that the A1298C-MTHFR polymorphism contributes to the genetic risk for both CIN and ICC, whereas the Arg72Pro-p53 polymorphism only contributes to the risk for CIN.
|
24474455 |
2014 |
rs397507444
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Interestingly, women with the MTHFR A1298C polymorphisms had a marginally increased susceptibility to invasive cancer (ICC) when compared with no carriers but no statistically significant difference in the dominant model (P = 0.06, OR = 1.21, 95% CI = 0.99-1.49) and AC vs. AA (P = 0.09, OR = 1.21, 95% CI = 0.97-1.51).
|
23285018 |
2012 |
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Their frequent BRAF V600E mutations support their neoplastic nature, but not necessarily their progression to ICC.
|
27627051 |
2017 |
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Their frequent BRAF V600E mutations support their neoplastic nature, but not necessarily their progression to ICC.
|
27627051 |
2017 |
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
They also support the hypothesis that mutated BDA might precede the development of the subset of intrahepatic cholangiocarcinomas harbouring BRAF V600E mutations.
|
25704541 |
2015 |
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
They also support the hypothesis that mutated BDA might precede the development of the subset of intrahepatic cholangiocarcinomas harbouring BRAF V600E mutations.
|
25704541 |
2015 |
rs113488022
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we demonstrate that BRAF V600E</span> mutation is a rare event in biliary tract cancer, accounting for only 1% of all subtypes, and is restricted to intrahepatic cholangiocarcinoma.
|
24309328 |
2014 |
rs121913377
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we demonstrate that BRAF V600E</span> mutation is a rare event in biliary tract cancer, accounting for only 1% of all subtypes, and is restricted to intrahepatic cholangiocarcinoma.
|
24309328 |
2014 |