rs371077728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Next-Generation Sequencing Reveals a Nonsense Mutation (p.Arg364Ter) in <i>MRE11A</i> Gene in an Indian Patient with Familial Breast Cancer.
|
28559769 |
2017 |
rs398122697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a previous study, two <i>de novo</i> BRCT missense mutations of <i>BRCA1</i>, G1763V and L1786P were identified from Chinese females with familial breast cancer.
|
29113215 |
2017 |
rs80357007
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a previous study, two <i>de novo</i> BRCT missense mutations of <i>BRCA1</i>, G1763V and L1786P were identified from Chinese females with familial breast cancer.
|
29113215 |
2017 |
rs11571833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context.
|
26455428 |
2015 |
rs152451
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs152451-G/rs45551636-C and rs152451-G/rs45551636-T haplotypes were associated with an increased BC risk only in cases with a strong family history of BC (OR = 1.6 [CI 95% 1.0-2.5] p = 0.05 and OR = 3.7 [CI 95% 1.8-7.5] p < 0.001, respectively).
|
25636233 |
2015 |
rs152451
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PALB2 c.1676A > G (rs152451A/G) and c.2993C > T (rs45551636C/T) variants were significantly associated with increased BC risk only in cases with a strong family history of BC (OR = 1.9 [CI 95% 1.3-2.8] p < 0.01 and OR = 3.3 [CI 95% 1.4-7.3] p < 0.01, respectively).
|
25636233 |
2015 |
rs28359178
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk.
|
25925750 |
2015 |
rs45551636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
PALB2 c.1676A > G (rs152451A/G) and c.2993C > T (rs45551636C/T) variants were significantly associated with increased BC risk only in cases with a strong family history of BC (OR = 1.9 [CI 95% 1.3-2.8] p < 0.01 and OR = 3.3 [CI 95% 1.4-7.3] p < 0.01, respectively).
|
25636233 |
2015 |
rs45551636
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs152451-G/rs45551636-C and rs152451-G/rs45551636-T haplotypes were associated with an increased BC risk only in cases with a strong family history of BC (OR = 1.6 [CI 95% 1.0-2.5] p = 0.05 and OR = 3.7 [CI 95% 1.8-7.5] p < 0.001, respectively).
|
25636233 |
2015 |
rs1057519975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor.
|
24114315 |
2014 |
rs1060915
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype.
|
25273865 |
2014 |
rs1131691036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor.
|
24114315 |
2014 |
rs12516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP c.*1287C>T (rs12516) of the BRCA1 gene may have potential use as a genetic marker of an increased risk of developing breast cancer and likely represents a non-coding sequence variation in BRCA1 that impacts BRCA1 function and leads to increased early-onset and/or familial breast cancer risk in the Turkish population.
|
25339023 |
2014 |
rs16940
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer</span> across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype.
|
25273865 |
2014 |
rs799917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype.
|
25273865 |
2014 |
rs11075884
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs13387042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs17663555
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs2046210
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs3112612
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs566164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
rs11200014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |
rs1219648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |
rs2420946
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |
rs2981582
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |