Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs77724903
rs77724903
RET
T 0.700 CausalMutation CLINVAR

dbSNP: rs1136201
rs1136201
0.010 GeneticVariation BEFREE A case-control study analysing a cohort of 348 German familial breast cancer cases and 960 corresponding controls showed no significant association of either Ile655Val (OR = 1.05, 95% CI = 0.82-1.34, P = 0.728) or Ala1170Pro (OR = 0.94, 95% CI = 0.74-1.20, P = 0.632) with familial breast cancer risk. 15550452

2005

dbSNP: rs1058808
rs1058808
0.010 GeneticVariation BEFREE A case-control study analysing a cohort of 348 German familial breast cancer cases and 960 corresponding controls showed no significant association of either Ile655Val (OR = 1.05, 95% CI = 0.82-1.34, P = 0.728) or Ala1170Pro (OR = 0.94, 95% CI = 0.74-1.20, P = 0.632) with familial breast cancer risk. 15550452

2005

dbSNP: rs28363284
rs28363284
0.020 GeneticVariation BEFREE A RAD51D variant, E233G, was initially identified as a potential susceptibility allele in high-risk, site-specific, familial breast cancer. 19347880

2009

dbSNP: rs34301344
rs34301344
0.040 GeneticVariation BEFREE ARLTS1 is a tumor suppressor gene initially described as a low-penetrance cancer gene: a truncated Trp149Stop (MUT) polymorphism is associated with general familial cancer aggregation and, particularly, high-risk familial breast cancer. 17079447

2006

dbSNP: rs755100942
rs755100942
0.040 GeneticVariation BEFREE ARLTS1 is a tumor suppressor gene initially described as a low-penetrance cancer gene: a truncated Trp149Stop (MUT) polymorphism is associated with general familial cancer aggregation and, particularly, high-risk familial breast cancer. 17079447

2006

dbSNP: rs13010627
rs13010627
0.010 GeneticVariation BEFREE Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant. 16251207

2006

dbSNP: rs1045485
rs1045485
0.010 GeneticVariation BEFREE Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant. 16251207

2006

dbSNP: rs3803185
rs3803185
0.030 GeneticVariation BEFREE Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. 16646072

2006

dbSNP: rs34301344
rs34301344
0.040 GeneticVariation BEFREE Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. 16646072

2006

dbSNP: rs755100942
rs755100942
0.040 GeneticVariation BEFREE Both Cys148Arg and Trp149Stop were associated with an increased risk of familial or high-risk familial breast cancer, respectively. 16646072

2006

dbSNP: rs121917739
rs121917739
0.010 GeneticVariation BEFREE Few studies have investigated the role of coding region variation in the RAD51 gene in familial breast cancer, with only one coding region variant--exon 6 c.449G>A (p.R150Q)--reported to date. 16762046

2006

dbSNP: rs1346044
rs1346044
WRN
0.010 GeneticVariation BEFREE Genotyping analyses, performed on 816 BRCA1/2 mutation-negative German familial breast cancer patients and 1012 German controls, revealed a significant association of the WRN Cys1367Arg polymorphism with familial breast cancer (OR = 1.28, 95% CI 1.06-1.54) and high-risk familial breast cancer (OR = 1.32, 95% CI 1.06-1.65). 16501249

2006

dbSNP: rs1695
rs1695
0.010 GeneticVariation BEFREE GSTP1 Ile105Val polymorphism was associated neither with sporadic nor familial breast cancer susceptibility (P value > 0.05). 18080216

2008

dbSNP: rs4645959
rs4645959
0.010 GeneticVariation BEFREE Here, we analysed the influence of the rare c-MYC Asn11Ser polymorphism on familial breast cancer risk by performing a case-control study with a Polish (cases n = 349; controls n = 441) and a German (cases n = 356; controls n = 655) study population. 15929079

2005

dbSNP: rs34434221
rs34434221
0.020 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs886039958
rs886039958
0.020 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs4843075
rs4843075
0.010 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs530464947
rs530464947
0.010 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs758898660
rs758898660
0.010 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs2241268
rs2241268
0.010 GeneticVariation BEFREE Here, we analysed the potential impact of four polymorphic non-conservative amino acid exchanges (Arg494Trp, Lys526Gln, Asn1086Asp and Gly2461Ser) in AKAP13 on familial breast cancer. 16234258

2006

dbSNP: rs1042522
rs1042522
0.020 GeneticVariation BEFREE Here, we investigated the possible role of the Ins16bp and Arg72Pro polymorphisms and their haplotypes as low-penetrance alleles in familial breast cancer. 18640791

2008

dbSNP: rs1131691014
rs1131691014
0.020 GeneticVariation BEFREE Here, we investigated the possible role of the Ins16bp and Arg72Pro polymorphisms and their haplotypes as low-penetrance alleles in familial breast cancer. 18640791

2008

dbSNP: rs878854066
rs878854066
0.020 GeneticVariation BEFREE Here, we investigated the possible role of the Ins16bp and Arg72Pro polymorphisms and their haplotypes as low-penetrance alleles in familial breast cancer. 18640791

2008

dbSNP: rs144567652
rs144567652
0.020 GeneticVariation BEFREE Here, we studied the prevalence of three other FANCM variants: c.5791C>T, which has been reported to predispose to familial breast cancer, and the c.4025_4026delCT and c.5293dupA variants recently identified in Finnish cancer patients. 28702895

2017