|
rs1042028
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk.
|
19863350 |
2010 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The R72P P53 mutation is associated with familial breast cancer in Jewish women.
|
15756275 |
2005 |
|
rs1042522
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we investigated the possible role of the Ins16bp and Arg72Pro polymorphisms and their haplotypes as low-penetrance alleles in familial breast cancer.
|
18640791 |
2008 |
|
rs1045485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
|
16251207 |
2006 |
|
rs1057519975
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor.
|
24114315 |
2014 |
|
rs1058808
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study analysing a cohort of 348 German familial breast cancer cases and 960 corresponding controls showed no significant association of either Ile655Val (OR = 1.05, 95% CI = 0.82-1.34, P = 0.728) or Ala1170Pro (OR = 0.94, 95% CI = 0.74-1.20, P = 0.632) with familial breast cancer risk.
|
15550452 |
2005 |
|
rs1060915
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype.
|
25273865 |
2014 |
|
rs1064795860
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified six patients (25%) with BRCA1 mutation of which three were found to be of novel type one in exon 16 (4956insG) and two in exon 7 (Lys110Thr) (Ser114Pro) out of 24 familial breast cancer patients studied from two different geographic regions/populations of India.
|
15564800 |
2004 |
|
rs11075884
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
|
rs11200014
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Here, we investigated the possible role of the Ins16bp and Arg72Pro polymorphisms and their haplotypes as low-penetrance alleles in familial breast cancer.
|
18640791 |
2008 |
|
rs1131691014
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The R72P P53 mutation is associated with familial breast cancer in Jewish women.
|
15756275 |
2005 |
|
rs1131691036
|
|
|
0.010 |
GeneticVariation |
BEFREE |
RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor.
|
24114315 |
2014 |
|
rs113211432
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results suggest that the contribution of the BARD1 germline variants to breast cancer predisposition is very limited, and that neither Cys557Ser nor Val507Met have an effect on familial breast cancer susceptibility.
|
16333312 |
2006 |
|
rs1136201
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A case-control study analysing a cohort of 348 German familial breast cancer cases and 960 corresponding controls showed no significant association of either Ile655Val (OR = 1.05, 95% CI = 0.82-1.34, P = 0.728) or Ala1170Pro (OR = 0.94, 95% CI = 0.74-1.20, P = 0.632) with familial breast cancer risk.
|
15550452 |
2005 |
|
rs11571833
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context.
|
26455428 |
2015 |
|
rs1186364060
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis of p53 MspI 1798G>A, which is completely linked to p53PIN3, showed a significantly increased familial breast cancer risk for carriers of the 16 bp insertion/duplication, following a recessive mode (OR = 2.15, 95% CI = 1.12-4.11).
|
16501249 |
2006 |
|
rs121917739
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Few studies have investigated the role of coding region variation in the RAD51 gene in familial breast cancer, with only one coding region variant--exon 6 c.449G>A (p.R150Q)--reported to date.
|
16762046 |
2006 |
|
rs1219648
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer.
|
22374580 |
2012 |
|
rs12255372
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest a possible influence of TCF7L2 rs12255372 on the risk of familial BC.
|
17109766 |
2006 |
|
rs12516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNP c.*1287C>T (rs12516) of the BRCA1 gene may have potential use as a genetic marker of an increased risk of developing breast cancer and likely represents a non-coding sequence variation in BRCA1 that impacts BRCA1 function and leads to increased early-onset and/or familial breast cancer risk in the Turkish population.
|
25339023 |
2014 |
|
rs13010627
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of the CASP10 V410I variant with reduced familial breast cancer risk and interaction with the CASP8 D302H variant.
|
16251207 |
2006 |
|
rs1302297709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This suggests a role for E233G as a low-penetrance susceptibility gene in the specific subgroup of high-risk familial breast cancer cases that are not related to BRCA1/2.
|
15170666 |
2004 |
|
rs13387042
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74.
|
23354978 |
2013 |
|
rs1346044
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotyping analyses, performed on 816 BRCA1/2 mutation-negative German familial breast cancer patients and 1012 German controls, revealed a significant association of the WRN Cys1367Arg polymorphism with familial breast cancer (OR = 1.28, 95% CI 1.06-1.54) and high-risk familial breast cancer (OR = 1.32, 95% CI 1.06-1.65).
|
16501249 |
2006 |