Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs371077728
rs371077728
0.010 GeneticVariation BEFREE Next-Generation Sequencing Reveals a Nonsense Mutation (p.Arg364Ter) in <i>MRE11A</i> Gene in an Indian Patient with Familial Breast Cancer. 28559769

2017

dbSNP: rs398122697
rs398122697
0.010 GeneticVariation BEFREE In a previous study, two <i>de novo</i> BRCT missense mutations of <i>BRCA1</i>, G1763V and L1786P were identified from Chinese females with familial breast cancer. 29113215

2017

dbSNP: rs80357007
rs80357007
0.010 GeneticVariation BEFREE In a previous study, two <i>de novo</i> BRCT missense mutations of <i>BRCA1</i>, G1763V and L1786P were identified from Chinese females with familial breast cancer. 29113215

2017

dbSNP: rs11571833
rs11571833
0.010 GeneticVariation BEFREE Reevaluation of the BRCA2 truncating allele c.9976A > T (p.Lys3326Ter) in a familial breast cancer context. 26455428

2015

dbSNP: rs152451
rs152451
0.010 GeneticVariation BEFREE The rs152451-G/rs45551636-C and rs152451-G/rs45551636-T haplotypes were associated with an increased BC risk only in cases with a strong family history of BC (OR = 1.6 [CI 95% 1.0-2.5] p = 0.05 and OR = 3.7 [CI 95% 1.8-7.5] p < 0.001, respectively). 25636233

2015

dbSNP: rs152451
rs152451
0.010 GeneticVariation BEFREE PALB2 c.1676A > G (rs152451A/G) and c.2993C > T (rs45551636C/T) variants were significantly associated with increased BC risk only in cases with a strong family history of BC (OR = 1.9 [CI 95% 1.3-2.8] p < 0.01 and OR = 3.3 [CI 95% 1.4-7.3] p < 0.01, respectively). 25636233

2015

dbSNP: rs28359178
rs28359178
CYTB ; ND5 ; ND6
0.010 GeneticVariation BEFREE We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. 25925750

2015

dbSNP: rs45551636
rs45551636
0.010 GeneticVariation BEFREE PALB2 c.1676A > G (rs152451A/G) and c.2993C > T (rs45551636C/T) variants were significantly associated with increased BC risk only in cases with a strong family history of BC (OR = 1.9 [CI 95% 1.3-2.8] p < 0.01 and OR = 3.3 [CI 95% 1.4-7.3] p < 0.01, respectively). 25636233

2015

dbSNP: rs45551636
rs45551636
0.010 GeneticVariation BEFREE The rs152451-G/rs45551636-C and rs152451-G/rs45551636-T haplotypes were associated with an increased BC risk only in cases with a strong family history of BC (OR = 1.6 [CI 95% 1.0-2.5] p = 0.05 and OR = 3.7 [CI 95% 1.8-7.5] p < 0.001, respectively). 25636233

2015

dbSNP: rs1057519975
rs1057519975
0.010 GeneticVariation BEFREE RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor. 24114315

2014

dbSNP: rs1060915
rs1060915
0.010 GeneticVariation BEFREE The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype. 25273865

2014

dbSNP: rs1131691036
rs1131691036
0.010 GeneticVariation BEFREE RAD51 135G>C contributes to hereditary breast cancer in Serbian population, with CC genotype as a risk factor. 24114315

2014

dbSNP: rs12516
rs12516
0.010 GeneticVariation BEFREE SNP c.*1287C>T (rs12516) of the BRCA1 gene may have potential use as a genetic marker of an increased risk of developing breast cancer and likely represents a non-coding sequence variation in BRCA1 that impacts BRCA1 function and leads to increased early-onset and/or familial breast cancer risk in the Turkish population. 25339023

2014

dbSNP: rs16940
rs16940
0.010 GeneticVariation BEFREE The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer</span> across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype. 25273865

2014

dbSNP: rs799917
rs799917
0.010 GeneticVariation BEFREE The association of four variants was identified within BRCA1 gene (c.442.58 delT, c.2311T>C, c.2612C>T and c.4308T>C) to familial breast cancer across their wild genotypes. miR-1179 was selected as potential miR that targets the region of BRCA1 mRNA containing the c.2311T>C variant within the TT genotype. 25273865

2014

dbSNP: rs11075884
rs11075884
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs13387042
rs13387042
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs17663555
rs17663555
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs2046210
rs2046210
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs3112612
rs3112612
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs566164
rs566164
0.010 GeneticVariation BEFREE Seven of the 19 markers were significant in a multivariate predictive model of familial breast cancer in AJ women, three novel SNPs [rs17663555(5q13.2), rs566164(6q21), and rs11075884(16q22.2)], the FGFR2 haplotype, and three previously published SNPs [rs13387042(2q35), rs2046210(ESR1), and rs3112612(TOX3)], yielding moderate predictive power with an area under the curve (AUC) of the ROC (receiver-operator characteristic curve) of 0.74. 23354978

2013

dbSNP: rs11200014
rs11200014
0.010 GeneticVariation BEFREE The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer. 22374580

2012

dbSNP: rs1219648
rs1219648
0.010 GeneticVariation BEFREE The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer. 22374580

2012

dbSNP: rs2420946
rs2420946
0.010 GeneticVariation BEFREE The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer. 22374580

2012

dbSNP: rs2981582
rs2981582
0.010 GeneticVariation BEFREE The data showed that the homozygotes at each minor allele, rs11200014 (AA), rs1219648 (GG), rs2420946 (TT), and rs2981582 (TT), were significantly associated with an increased risk of early-onset non-familial breast cancer. 22374580

2012