Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. 30084963

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Trend level gene-gender interaction effect for the BDNF rs6265 variant on age of onset of psychosis. 31445421

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum. 29785763

2019

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. 31822818

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The BDNF-Val66Met polymorphism may index susceptibility to expression of psychosis along a spectrum. 29785763

2019

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Chronic methamphetamine interacts with BDNF Val66Met to remodel psychosis pathways in the mesocorticolimbic proteome. 31822818

2019

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The interaction between cannabis use and the Val158Met polymorphism of the COMT gene in psychosis: A transdiagnostic meta - analysis. 29444152

2018

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The relationship of performance errors with catechol-O-methyltransferase (COMT) rs4680 (Val158Met) genotype (Met carriers vs. Val homozygotes) on test performance before and after antipsychotic treatment in 32 first episode psychosis (FEP) patients was examined. 29941295

2018

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis. 27629407

2018

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE This study suggests that the common Val66Met polymorphism of the BDNF gene may modulate the relationship between life stress and calorie intake in subjects at risk for psychosis. 27629407

2018

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE A functional polymorphism in the catechol-O-methyltransferase (COMT) gene (Val158Met) appears to influence cognition in people with alcohol/substance use disorders (AUD/SUD) and in those with psychosis. 28635556

2017

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. 28142064

2017

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns. 28142064

2017

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns. 28142064

2017

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE COMT Val(158)Met genotype and cannabis use in people with an At Risk Mental State for psychosis: Exploring Gene x Environment interactions. 27052366

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE One of the most studied genetic phenotypes for psychosis is brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms. 26603624

2016

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE One of the most studied genetic phenotypes for psychosis is brain-derived neurotrophic factor (BDNF) Val66Met polymorphisms. 26603624

2016

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The present findings indicate that rs6265 is associated with METH dependence in the Thai population, with the GG genotype greater in METH-dependent subjects but reducing the emergence of METH-dependent psychosis. 26401760

2015

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE Further, our study supports a two hit model including a history of childhood trauma as well as genetic vulnerability (met carriers of the BDNF val66met) behind reduced volume of hippocampal subfields in psychosis. 25246365

2014

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE Further, our study supports a two hit model including a history of childhood trauma as well as genetic vulnerability (met carriers of the BDNF val66met) behind reduced volume of hippocampal subfields in psychosis. 25246365

2014

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Although a polymorphism in this gene, COMT Val(158)Met, affects human behavior in response to stress little is known about its effect on dopaminergic activity associated with the human stress response, which may be of interest for stress-related psychiatric disorders such as psychosis. 23799032

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both neuropsychological performance and brain structure in patients with psychosis, in their relatives and in healthy individuals (step 1). 23527885

2013

dbSNP: rs6265
rs6265
0.100 GeneticVariation BEFREE The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis. 23748016

2013

dbSNP: rs759834365
rs759834365
0.100 GeneticVariation BEFREE The present study aimed to explore possible effects of BDNF Val66Met polymorphism variations on progressive structural brain changes after 3 years from the first episode of psychosis. 23748016

2013

dbSNP: rs4680
rs4680
0.100 GeneticVariation BEFREE Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype. 22128864

2012