Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs121913500
rs121913500
0.010 GeneticVariation BEFREE This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion. 31846689

2020

dbSNP: rs12976445
rs12976445
0.010 GeneticVariation BEFREE Further the heterozygous CT of miR-196a2 (rs11614913) (OR-1.88, CI-1.06 to 3.35, p-0.02) and homozygous CC of miR-125a (rs12976445) (OR-2.55, CI -1.15 to 4.65, p-0.03) showed increased risk for prostate cancer. 29594807

2020

dbSNP: rs13426236
rs13426236
0.010 GeneticVariation BEFREE This study provides strong evidence showing that prostate cancer risk SNP rs13426236 upregulates expression of MLPH transcript V4, which may function as a candidate oncogene in prostate cancer. 31659808

2020

dbSNP: rs35672330
rs35672330
0.010 GeneticVariation BEFREE We found two other EXO5 SNPs significantly associated with risk of PCa in cases-controls study from databases of genotype and phenotype (dbGaP), which are in linkage disequilibrium (D' = 1) with Exo5 L151P found in PCa family. 31616062

2020

dbSNP: rs57095329
rs57095329
0.010 GeneticVariation BEFREE Statistical analysis revealed the heterozygous AG genotype of the rs57095329 was significantly decreased in the cases when compared to the controls (OR-0.45, CI -0.24 to 0.85, p value-0.02) indicating an inverse association of this genotype with prostate cancer. 29594807

2020

dbSNP: rs772893086
rs772893086
0.010 GeneticVariation BEFREE This study demonstrates that IDH1 R132H mutation with increased oncometabolite R-2HG in PCa cells may play important roles to increase PCa cell invasion. 31846689

2020

dbSNP: rs919467999
rs919467999
ERG
0.010 GeneticVariation BEFREE We found two other EXO5 SNPs significantly associated with risk of PCa in cases-controls study from databases of genotype and phenotype (dbGaP), which are in linkage disequilibrium (D' = 1) with Exo5 L151P found in PCa family. 31616062

2020

dbSNP: rs1046040
rs1046040
0.010 GeneticVariation BEFREE Haplotype analysis proposed that rs3787016 T/rs1046040 C significantly increased the risk of PCa compared to C/C (p = 0.037). 30587086

2019

dbSNP: rs1047840
rs1047840
0.010 GeneticVariation BEFREE Our results suggest that CDH1 -160C/A and Exo1 K589E polymorphisms are associated with increased susceptibility to prostate cancer in Bangladeshi population. 30880589

2019

dbSNP: rs1076064
rs1076064
0.010 GeneticVariation BEFREE Since miRNA-based mechanisms are shown to be involved in the pathogenesis of prostate cancer (PCa), the aim of the present study was to evaluate the effect of rs4938723, rs1076064 and rs4705343 occurring in regulatory regions of miR-34b/c, miR-143/145 and miR-378, respectively, on PCa risk and progression in Serbian population. 31423132

2019

dbSNP: rs1125927
rs1125927
0.010 GeneticVariation BEFREE We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population. 31562322

2019

dbSNP: rs1126647
rs1126647
0.010 GeneticVariation BEFREE The A T A haplotype (rs4073, rs2227306 and rs112</span>6647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03). 30641210

2019

dbSNP: rs11639084
rs11639084
0.010 GeneticVariation BEFREE The rs11639084 and rs4774388 alleles were not different between PCa and normal groups 95% CI: 0.52-1.24, OR = 1.04, P = .34; 95% CI: 0.48-1.33, OR = .79, P = .39 respectively. 30251751

2019

dbSNP: rs1192131078
rs1192131078
0.010 GeneticVariation BEFREE Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 (<i>KLK3</i>) gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk (<i>P</i> = 2.3 × 10<sup>-8</sup>). 30538125

2019

dbSNP: rs12680047
rs12680047
0.010 GeneticVariation BEFREE Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk. 30914434

2019

dbSNP: rs138708
rs138708
0.010 GeneticVariation BEFREE We found 12 novel loci for PCa including rs1125927 (TMEM17, P = 3.95 × 10<sup>-16</sup>), rs73862213 (GATA2, P = 5.87 × 10<sup>-23</sup>), rs77911174 (ZMIZ1, P = 5.28 × 10<sup>-20</sup>), and rs138708 (SUN2, P = 1.13 × 10<sup>-15</sup>), seven of which had crucially low minor allele frequency in European population. 31562322

2019

dbSNP: rs1569686
rs1569686
0.010 GeneticVariation BEFREE Although there was no consistent evidence of an association between DNMT3B variants and PCa mortality, the TT genotype of rs1569686 was associated with LINE-1 hypomethylation in tumor tissue and DNMT3B mRNA expression was associated with an increased risk of lethal PCa. 30341411

2019

dbSNP: rs16902359
rs16902359
0.010 GeneticVariation BEFREE Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with prostate cancer risk. 30914434

2019

dbSNP: rs1799796
rs1799796
0.010 GeneticVariation BEFREE A significant association was detected between <i>RAD51</i> rs5030789 polymorphism and <i>XRCC3</i> rs1799796 polymorphism and an increased risk of prostate cancer. 31186630

2019

dbSNP: rs1815009
rs1815009
0.010 GeneticVariation BEFREE The results of the present study revealed an association between rs1815009, rs2684788 and PCa risk, which involves altered miRNA regulation and contributes to cancer susceptibility. 30365147

2019

dbSNP: rs2069845
rs2069845
IL6
0.010 GeneticVariation BEFREE However, the frequency of rs</span>2069845 variants was not significantly different between PCa, BPH and control groups. 30345492

2019

dbSNP: rs2227306
rs2227306
0.010 GeneticVariation BEFREE The A T A haplotype (rs4073, rs2227306 and rs1126647 respectively) was less frequent in PCa group compared with BPH group (OR (95% CI) = 0.4 (0.22-0.75), adjusted P value = 0.03). 30641210

2019

dbSNP: rs2297441
rs2297441
0.010 GeneticVariation BEFREE <i>RTEL1</i> rs2297441 [odds ratio (OR): 1.23; 95% confidence interval (CI): 1.03-1.46, <i>P</i> = 0.021] and rs3208008 (OR: 1.23; 95% CI: 1.03-1.46) were associated with PCa risk. 31762827

2019

dbSNP: rs2301241
rs2301241
TXN
0.010 GeneticVariation BEFREE With respect to acrylamide-gene interactions, only rs1800566 in NAD(P)H quinone dehydrogenase 1 (NQO1) and rs2301241 in thioredoxin (TXN) showed a nominally statistically significant multiplicative interaction with acrylamide intake for advanced prostate cancer risk. 29697282

2019

dbSNP: rs2308327
rs2308327
0.010 GeneticVariation BEFREE However, the data suggest the rs2308327 and rs2308321 polymorphisms of the MGMT gene were nor associated with the susceptibility of prostate cancer. 31190217

2019