DisGeNET - a database of gene-disease associations

Malignant neoplasm of prostate, C0376358

Variant: rs149709822 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs149709822

KLK3

0.040

GeneticVariation

BEFREE

This study tested the interactions of VDR (CDX2, FokI) and SRD5A2 (V89L, A49T) polymorphisms, and their associations with prostate cancer.

18483391

2008

dbSNP:

rs149709822

KLK3

0.040

GeneticVariation

BEFREE

Cytosine-adenine-guanine repeat length of the androgen receptor gene and the A49T and V89L polymorphisms of the 5 alpha-reductase (SRD5A2) gene have been associated with prostate cancer.

12210487

2002

dbSNP:

rs149709822

KLK3

0.040

GeneticVariation

BEFREE

The SRD5A2 V89L and A49T polymorphisms were, however, not associated with altered prostate cancer risk.

12042668

2002

dbSNP:

rs149709822

KLK3

0.040

GeneticVariation

BEFREE

Our results suggest that the A49T mutation may influence the pathological characteristics of prostate cancers and, thus, may affect the prognosis of these patients.

10749132

2000