|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Nevertheless, rs627928 was reported to promote the development of prostate cancer (T vs. G: OR=1.08, 95% CI=1.01-1.15; TT+TG vs. GG: OR=1.14, 95% CI=1.03-1.25) in allele and recessive models in overall populations.
|
31686670 |
2019 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Our study provides the proof-of-principle that some of the genetic variants (such as rs486907, rs627928 and rs2127565) in genes RNASEL, MSR1 and ELAC2 can be used as predictors of aggressiveness and progression of PCa.
|
26251261 |
2015 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
To study the association between the polymorphisms Arg462Gln and Asp541Glu from the RNASEL gene (1q25), and the polymorphisms rs620861, rs1447295, rs6983267, rs7837328 from the chromosome 8q24 with the risk of presenting prostate cancer (PCa) and its clinical characteristics in a Hispanic (Chilean) population.
|
24224612 |
2014 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
However, we found the significant association of RNASEL Asp541Glu polymorphism with sporadic PCa (Glu/Glu vs. Asp/Asp: OR 1.29, 95% CI: 1.04-1.59, P = 0.02; Glu/Asp vs. Asp/Asp: OR 1.24, 95% CI: 1.03-1.50, P = 0.03).
|
21656378 |
2012 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found no evidence of association between R462Q and D541E polymorphisms and prostate cancer risk in our case/control analysis.
|
18189233 |
2008 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We examined polymorphisms within ELAC2 (S217L, A541T, E622V), MSR1 (P275A, R293X, aIVS5-59c), and RNASEL (E265X, R462Q, D541E) in 150 European-Americans with metastatic prostate cancer and 170 prostate cancer-free controls using pyrosequencing assays.
|
16114055 |
2006 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Compared with the genotype Asp/Asp, the Glu variant at the Asp541Glu polymorphism increases prostate cancer risk by <2-fold in Caucasians, regardless of family history of the disease.
|
17020975 |
2006 |
|
rs627928
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We found a marginally significant inverse association between the missense mutation D541E and sporadic prostate cancer risk (odds ratio, 0.77; 95% confidence interval, 0.59-1.00) and reduced risk of prostate cancer in carriers of two different haplotypes being completely discordant.
|
15534086 |
2004 |